Gut resistome of preschool children after prolonged mass azithromycin distribution: a cluster-randomized trial.


We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. While the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs.

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Lee Worden

Research Specialist
University of California San Francisco

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