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Modeling the cost-effectiveness and impact on fatal overdose and initiation of buprenorphine-naloxone treatment at syringe service programs.

Abstract

To estimate the number of treatment initiations, averted fatal opioid overdoses, and the cost-effectiveness associated with offering buprenorphine-naloxone (buprenorphine) treatment on-site within existing syringe service programs (SSPs) in Massachusetts, USA.

Cohort-based mathematical model and cost-effectiveness analysis. We derived model inputs from state and national surveillance data, clinical trials, and observational cohort studies. We compared an intervention scenario where 30% of SSP clients-initiated buprenorphine treatment on-site at least once annually to a status quo scenario where no buprenorphine was available onsite.

Community treatment providers in Massachusetts, 2020-2030 PARTICIPANTS: Individuals with opioid use disorder (OUD). We assumed that 80% of SSP clients had recently injected drugs and that treatment within SSPs would have similar or improved retention compared with standard-of-care buprenorphine programs, but higher rates of active opioid use while in treatment.

The status quo scenario resulted in 23,051 fatal overdoses and 1,511,613 treatment initiations over a 10-year simulation period. An intervention scenario with on-site SSP buprenorphine treatment averted 5,015 (-20.8%) fatal opioid overdoses and resulted in 129,359 (+8.6%) additional treatment initiations compared with the status quo. The intervention scenario was the dominating scenario: providing OUD treatment through Massachusetts SSPs cost less (-$3,600 per person), resulting in $775 million in total estimated savings over 10 years, with patients accumulating more QALYs (0.2 per person) compared with the status quo scenario.

Number of treatment initiations (i.e., individuals began treatment on a medication for opioid use disorder or entered medically managed withdrawal), averted fatal opioid overdoses, quality-adjusted life-years (QALYs), and lifetime discounted costs from a health sector and a limited societal perspective.

Offering buprenorphine treatment on-site within syringe service programs has the potential to decrease fatal overdoses substantially, improve treatment engagement, and save on costs.

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Citation:

Adams JW, Savinkina A, Fox A, Behrends CN, Madushani RWMA, Wang J, Chatterjee A, Walley AY, Barocas JA, Linas BP. (2022). Modeling the cost-effectiveness and impact on fatal overdose and initiation of buprenorphine-naloxone treatment at syringe service programs. Addiction (Abingdon, England)

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