The purpose of this Notice of Special Interest (NOSI) is to announce that the National Institute of Allergy and Infectious Diseases (NIAID) is encouraging applications to advance research activities relevant to systems modeling of infection and immunity. Recipients will collaborate with the Center of Excellence (CoE) for Systems Modeling of Infection and Immunity across Biological Scales (U54 Clinical Trial Not Allowed) described in RFA-AI-23-077. The CoE will coordinate the program, working with NIAID, and set up collaborations with recipients to participate in CoE activities.
Background
Computational modeling can: (1) elucidate biological mechanisms of infection and/or transmission, (2) understand immune system regulation and responses to various triggers (commensal and pathogenic organisms, vaccines, environment, autoantigens), (3) characterize longitudinal trajectories of allergic or immune-mediated diseases from initiation through progression and/or resolution, including across the lifespan and effects of microbiome, (4) optimize public health control measures in response to epidemic threats, and (5) inform epidemic trajectories and develop therapeutic interventions. Computational modeling projects are often siloed from other modeling projects, limiting their reuse, multiscale integration, transferability, and public health utility. There is a need to support a coordinated, collaborative network of computational modeling across the infectious and immune-mediated disease (IID) research community. Recipients will engage with the CoE to foster a collaborative modeling community supported by NIAID.
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