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Does seasonal influenza vaccination increase the risk of illness with the 2009 A/H1N1 pandemic virus?

Abstract

This Perspective discusses the following study published in PLoS Medicine: Skowronski DM, De Serres G, Crocroft N, Janjua NZ, Boulianne N, et al. (2010) Association between the 2008-09 Seasonal Influenza Vaccine and Pandemic H1N1 Illness during Spring-Summer 2009 : Four Observational Studies from Canada. PLoS Med 7(4): e1000258. doi:10.1371/journal.pmed.1000258. In three case-control studies and a household transmission cohort, Danuta Skowronski and colleagues find an association between prior seasonal flu vaccination and increased risk of 2009 pandemic H1N1 flu.

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