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Evolutionary gain and loss of a pathological immune response to parasitism.

Abstract

. Extensive peritoneal fibrosis and inflammation are a commonly observed phenotype that contributes to suppression of cestode growth and viability but also imposes a substantial cost on fecundity. Combining genetic mapping and population genomics, we find that opposing selection generates immune system differences between tolerant and resistant populations, consistent with divergent optimization.

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Citation:

Weber JN, Steinel NC, Peng F, Shim KC, Lohman BK, Fuess LE, Subramanian S, Lisle SP, Bolnick DI. (2022). Evolutionary gain and loss of a pathological immune response to parasitism. Science (New York, N.Y.), 377(6611)

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