in LPS-injected animals, suggesting an increased sensitivity of cortical mitochondria to hypoxemia. This increased sensitivity was accompanied by a decrease in cortical oxygenation, but was attenuated by hypothermia. These results suggest that systemic endotoxemia influences cortical oxygenation and mitochondrial function, and that therapeutic hypothermia can be protective.
Chisholm KI, Ida KK, Davies AL, Tachtsidis I, Papkovsky DB, Dyson A, Singer M, Duchen MR, Smith KJ. (2016). Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 36(11)