. Cost-effective analysis was applied to investigate the most cost-effective strategy from various combination of control strategies. The results show that strategy combining all the control variables is the most cost-effective strategy followed by the strategy involving both personal-protection, the vaccination-only strategy was the least cost-effective. Although vaccination strategy is not cost-effective in this study, it is as effective in curtailing the infection as the other two control strategies. The study suggests that governments of communities with limited resources should consider complementing the use of vaccine with the use of facial mask particularly in hard-to-reach places in their communities.