Sphingosine-1-phosphate induces airway smooth muscle cell proliferation, migration, and contraction by modulating Hippo signaling effector YAP.
and modulating ROCK/YAP/FOXM1 axis and suggests that targeting this pathway might have potential value in the management of asthma.
American journal of physiology. Lung cellular and molecular physiology
Liu L, Zhai C, Pan Y, Zhu Y, Shi W, Wang J, Yan X, Su X, Song Y, Gao L, Li M. (2018). Sphingosine-1-phosphate induces airway smooth muscle cell proliferation, migration, and contraction by modulating Hippo signaling effector YAP. American journal of physiology. Lung cellular and molecular physiology, 315(4)
Assistant ProfessorJohns Hopkins University Continue Reading Li Gao