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Vancomycin Heteroresistance and Clinical Outcomes in Coagulase-Negative Staphylococcal Bloodstream Infections.

Abstract

= 0.001). This effect persisted after controlling for identified confounders. These data indicate that vancomycin heteroresistance is common in CoNS isolates from CLABSIs in pediatric patients with leukemia and is associated with poor clinical outcomes. Validation of these findings in an independent cohort and evaluation of alternative antibiotic therapy in patients with heteroresistant infections has the potential to improve care for serious CoNS infections.

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