The Anderson Laboratory develops and investigates next generation vaccines. Traditional vaccine approaches have led to over 20 human vaccines, one of the greatest preventative medical achievements of the last century. Unfortunately, these classic approaches have been ineffective in inducing long-lasting, protective immunity against the remaining majority of human pathogens. Exciting new approaches have recently emerged in the world of vaccine research including novel delivery techniques (e.g. mRNA Lipid-nanoparticles and viral-vector) and regimens (e.g. bivalent vaccines and heterologous-prime-boost). The Anderson Laboratory incorporates novel computational modeling and state-of-the-art experimental approaches to develop and understand next generation vaccines with an aim to induce long-lasting, broadly-neutralizing, humoral immunity to viruses such as Respiratory Syncytial Virus (RSV), Influenza, Human immunodeficiency virus (HIV), and SARS-CoV-2.
He/him/his
United States
Senff JR, Tack RWP, Tan BYQ, Prapiadou S, Kimball TN, Ng S, Duskin J, Shah-Ostrowski MJ, Nunley C, Brouwers HB, Chemali Z, Fricchione G, Tanzi RE, Pouwels K, Rosand J, Yechoor N, Anderson CD, Singh SD. (2025). Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort. Scientific reports, 15(1)
Senff JR, Shah-Ostrowski MJ, Tack RWP, Nunley C, Palys CR, Ng S, Mallick A, Gutierrez-Martinez L, Duskin J, Kimball TN, Prapiadou S, Marini S, Reinders E, Sherman K, Tinoble A, Brouwers HB, Akhavan S, Towfighi A, Rivier CA, Falcone GJ, Sheth K, Lazar RM, Ibrahim S, Pikula A, Chemali Z, van Duijn C, Fricchione G, Tanzi RE, Yechoor N, Anderson CD, Greenaway VP, Pouwels KB, Rosand J, Singh SD. (2025). U.S. public perceptions on whether risk of dementia and stroke can be modified through maintaining or changing lifestyle. BMC public health, 25(1)
Farner JE, Howard M, Smith JR, Anderson CB, Mordecai EA. (2025). Local tree cover predicts mosquito species richness and disease vector presence in a tropical countryside landscape. Landscape ecology, 40(6)
Ng SCW, Senff JR, Tack RWP, Maulik M, Shah-Ostrowski MJ, Ibrahim S, Tan BYQ, Prapriadou S, Kimball TN, Choksi D, Nunley C, Towfighi A, van Duijn C, Yechoor N, Pouwels K, Pikula A, Rosand J, Anderson CD, Singh SD. (2025). Associations Between Trust in Healthcare Professionals and Perceptions of Modifiability of Dementia and Stroke Risks Through Maintaining or Changing Lifestyle Habits. American journal of health promotion : AJHP
Bender W, Zhang Y, Corbett A, Chu C, Grier A, Wang L, Qiu X, McCall MN, Topham DJ, Walsh EE, Mariani TJ, Scheuermann R, Caserta MT, Anderson CS. (2024). Association of disease severity and genetic variation during primary Respiratory Syncytial Virus infections. BMC medical genomics, 17(1)
Zhou T, Gilliam NJ, Li S, Spaudau S, Osborn RM, Anderson CS, Mariani TJ, Thakar J, Dewhurst S, Mathews DH, Huang L, Sun Y. (2022). Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection. bioRxiv : the preprint server for biology
Anderson CS, Chirkova T, Slaunwhite CG, Qiu X, Walsh EE, Anderson LJ, Mariani TJ. (2021). CX3CR1 Engagement by Respiratory Syncytial Virus Leads to Induction of Nucleolin and Dysregulation of Cilia-related Genes. Journal of virology
Martinez-Sobrido L, Blanco-Lobo P, Rodriguez L, Fitzgerald T, Zhang H, Nguyen P, Anderson CS, Holden-Wiltse J, Bandyopadhyay S, Nogales A, DeDiego ML, Wasik BR, Miller BL, Henry C, Wilson PC, Sangster MY, Treanor JJ, Topham DJ, Byrd-Leotis L, Steinhauer DA, Cummings RD, Luczo JM, Tompkins SM, Sakamoto K, Jones CA, Steel J, Lowen AC, Danzy S, Tao H, Fink AL, Klein SL, Wohlgemuth N, Fenstermacher KJ, El Najjar F, Pekosz A, Sauer L, Lewis MK, Shaw-Saliba K, Rothman RE, Liu ZY, Chen KF, Parrish CR, Voorhees IEH, Kawaoka Y, Neumann G, Chiba S, Fan S, Hatta M, Kong H, Zhong G, Wang G, Uccellini MB, García-Sastre A, Perez DR, Ferreri LM, Herfst S, Richard M, Fouchier R, Burke D, Pattinson D, Smith DJ, Meliopoulos V, Freiden P, Livingston B, Sharp B, Cherry S, Dib JC, Yang G, Russell CJ, Barman S, Webby RJ, Krauss S, Danner A, Woodard K, Peiris M, Perera RAPM, Chan MCW, Govorkova EA, Marathe BM, Pascua PNQ, Smith G, Li YT, Thomas PG, Schultz-Cherry S. (2020). Characterizing Emerging Canine H3 Influenza Viruses. PLoS pathogens, 16(4)
Anderson CS, Sangster MY, Yang H, Mariani TJ, Chaudhury S, Topham DJ. (2020). Implementing sequence-based antigenic distance calculation into immunological shape space model. BMC Bioinformatics, 21(1)
C-Y Chu, L Wang, X Qiu, M McCall, A Corbett, J Holden-Wiltse, C Slaunwhite, Q Wang, CS Anderson, A Grier, SR Gill, AR Falsey, DJ Topham, MT Caserta, EE Walsh, TJ Mariani. (2019). Insufficiency in Airway Interferon Activation Defines Clinically Severe Infant RSV Infection. American Journal of Respiratory and Critical Care Medicine
Christopher S Anderson, Thomas J Mariani. (2019). Computer-Optimized Immunization Strategy to Boost Highly Cross-Reactive Antibodies to RSV. The Journal of Immunology, 202(1 Supplement)
Chin-Yi Chu, Xing Qiu, Matthew N McCall, Lu Wang, Anthony Corbett, Jeanne Holden-Wiltse, Christopher Slaunwhite, Qian Wang, Christopher Anderson, Alex Grier, Steven R Gill, Gloria S Pryhuber, Ann R Falsey, David J Topham, Mary T Caserta, Edward E Walsh, Thomas J Mariani. (2019). Insufficiency in airway interferon activation defines clinical severity to infant RSV infection. bioRxiv
Ha B, Chirkova T, Boukhvalova MS, Sun HY, Walsh EE, Anderson CS, Mariani TJ, Anderson LJ. (2019). Mutation of Respiratory Syncytial Virus G Protein's CX3C Motif Attenuates Infection in Cotton Rats and Primary Human Airway Epithelial Cells. Vaccines, 7(3)
Wang Q, Bhattacharya S, Mereness JA, Anderson C, Lillis JA, Misra RS, Romas S, Huyck H, Howell A, Bandyopadhyay G, Donlon K, Myers JR, Ashton J, Pryhuber GS, Mariani TJ. (2020). A novel in vitro model of primary human pediatric lung epithelial cells. Pediatric research, 87(3)
Christopher S Anderson, Mark Y Sangster, Hongmei Yang, Sidhartha Chaudhury, David J Topham. (2019). Computer Simulations of the Humoral Immune System Reveal How Imprinting Can Affect Responses to Influenza HA Stalk with Implications for the Design of Universal Vaccines. bioRxiv
Anderson CS, Chu CY, Wang Q, Mereness JA, Ren Y, Donlon K, Bhattacharya S, Misra RS, Walsh EE, Pryhuber GS, Mariani TJ. (2020). CX3CR1 as a respiratory syncytial virus receptor in pediatric human lung. Pediatric Research, 87(5)
Jared A Mereness, Soumyaroop Bhattacharya, Yue Ren, Qian Wang, Christopher S Anderson, Kathy Donlon, Andrew M Dylag, Jeannie Haak, Alessia Angelin, Paolo Bonaldo, Thomas J Mariani. (2019). Collagen VI Deficiency Results in Structural Abnormalities in the Mouse Lung. The American Journal of Pathology, 190(2)
Gaylo-Moynihan A, Prizant H, Popović M, Fernandes NRJ, Anderson CS, Chiou KK, Bell H, Schrock DC, Schumacher J, Capece T, Walling BL, Topham DJ, Miller J, Smrcka AV, Kim M, Hughson A, Fowell DJ. (2019). Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites. Immunity, 51(2)
Tesini BL, Kanagaiah P, Wang J, Hahn M, Halliley JL, Chaves FA, Nguyen PQT, Nogales A, DeDiego ML, Anderson CS, Ellebedy AH, Strohmeier S, Krammer F, Yang H, Bandyopadhyay S, Ahmed R, Treanor JJ, Martinez-Sobrido L, Golding H, Khurana S, Zand MS, Topham DJ, Sangster MY. (2019). Broad Hemagglutinin-Specific Memory B Cell Expansion by Seasonal Influenza Virus Infection Reflects Early-Life Imprinting and Adaptation to the Infecting Virus. Journal of virology, 93(8)
Anderson CS, McCall PR, Stern HA, Yang H, Topham DJ. (2018). Antigenic cartography of H1N1 influenza viruses using sequence-based antigenic distance calculation. BMC bioinformatics, 19(1)
Zhang H, Henry C, Anderson CS, Nogales A, DeDiego ML, Bucukovski J, Martinez-Sobrido L, Wilson PC, Topham DJ, Miller BL. (2018). Crowd on a Chip: Label-Free Human Monoclonal Antibody Arrays for Serotyping Influenza. Analytical chemistry, 90(15)
Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML. (2018). Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain. Scientific reports, 8(1)
Clark AM, DeDiego ML, Anderson CS, Wang J, Yang H, Nogales A, Martinez-Sobrido L, Zand MS, Sangster MY, Topham DJ. (2017). Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins. PloS one, 12(11)
Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML. (2017). Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain. Scientific reports, 7(1)
Anderson CS, DeDiego ML, Topham DJ, Thakar J. (2016). Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection. Computational and mathematical methods in medicine, (2016)
DeDiego ML, Anderson CS, Yang H, Holden-Wiltse J, Fitzgerald T, Treanor JJ, Topham DJ. (2016). Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine-mediated immune protection. Immunology, 148(2)
Anderson CS, DeDiego ML, Thakar J, Topham DJ. (2016). Novel Sequence-Based Mapping of Recently Emerging H5NX Influenza Viruses Reveals Pandemic Vaccine Candidates. PloS one, 11(8)
Stevenson C, de la Rosa G, Anderson CS, Murphy PS, Capece T, Kim M, Elliott MR. (2014). Essential role of Elmo1 in Dock2-dependent lymphocyte migration. Journal of immunology (Baltimore, Md. : 1950), 192(12)
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