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Eva Harris

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Papers

Puerta-Guardo H, Tabata T, Petitt M, Dimitrova M, Glasner DR, Pereira L, Harris E. (2019). Zika Virus Non-Structural Protein 1 Disrupts Glycosaminoglycans and Causes Permeability in Developing Human Placentas. The Journal of infectious diseases

Andrade P, Gimblet-Ochieng C, Modirian F, Collins M, Cárdenas M, Katzelnick LC, Montoya M, Michlmayr D, Kuan G, Balmaseda A, Coloma J, de Silva AM, Harris E. (2019). Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika. Nature communications, 10(1)

Sharma M, Glasner DR, Watkins H, Puerta-Guardo H, Kassa Y, Egan MA, Dean H, Harris E. (2019). Magnitude and Functionality of the NS1-Specific Antibody Response Elicited by a Live-Attenuated Tetravalent Dengue Vaccine Candidate. The Journal of infectious diseases

Bustos Carrillo F, Collado D, Sanchez N, Ojeda S, Lopez Mercado B, Burger-Calderon R, Gresh L, Gordon A, Balmaseda A, Kuan G, Harris E. (2019). Epidemiological Evidence for Lineage-Specific Differences in the Risk of Inapparent Chikungunya Virus Infection. Journal of virology, 93(4)

Espinosa DA, Beatty PR, Reiner GL, Sivick KE, Hix Glickman L, Dubensky TW Jr., Harris E. (2019). Cyclic Dinucleotide-Adjuvanted Dengue Virus Nonstructural Protein 1 Induces Protective Antibody and T Cell Responses. Journal of immunology (Baltimore, Md. : 1950), 202(4)

Andrade DV, Warnes C, Young E, Katzelnick LC, Balmaseda A, de Silva AM, Baric RS, Harris E. (2019). Tracking the polyclonal neutralizing antibody response to a dengue virus serotype 1 type-specific epitope across two populations in Asia and the Americas. Scientific reports, 9(1)

Puerta-Guardo H, Glasner DR, Espinosa DA, Biering SB, Patana M, Ratnasiri K, Wang C, Beatty PR, Harris E. (2019). Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism. Cell reports, 26(6)

Bustos Carrillo F, Gordon A, Harris E. (2019). Reply to Gérardin et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 68(1)

Gordon A, Gresh L, Ojeda S, Katzelnick LC, Sanchez N, Mercado JC, Chowell G, Lopez B, Elizondo D, Coloma J, Burger-Calderon R, Kuan G, Balmaseda A, Harris E. (2019). Prior dengue virus infection and risk of Zika: A pediatric cohort in Nicaragua. PLoS medicine, 16(1)

Sam IC, Montoya M, Chua CL, Chan YF, Pastor A, Harris E. (2019). Low seroprevalence rates of Zika virus in Kuala Lumpur, Malaysia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 113(11)

Wang C, Puerta-Guardo H, Biering SB, Glasner DR, Tran EB, Patana M, Gomberg TA, Malvar C, Lo NTN, Espinosa DA, Harris E. (2019). Endocytosis of flavivirus NS1 is required for NS1-mediated endothelial hyperpermeability and is abolished by a single N-glycosylation site mutation. PLoS pathogens, 15(7)

Glasner DR, Puerta-Guardo H, Beatty PR, Harris E. (2018). The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and Pathogenesis. Annual review of virology, 5(1)

Michlmayr D, Pak TR, Rahman AH, Amir ED, Kim EY, Kim-Schulze S, Suprun M, Stewart MG, Thomas GP, Balmaseda A, Wang L, Zhu J, Suaréz-Fariñas M, Wolinsky SM, Kasarskis A, Harris E. (2018). Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases. Molecular systems biology, 14(8)

Katzelnick LC, Ben-Shachar R, Mercado JC, Rodriguez-Barraquer I, Elizondo D, Arguello S, Nuñez A, Ojeda S, Sanchez N, Lopez Mercado B, Gresh L, Burger-Calderon R, Kuan G, Gordon A, Balmaseda A, Harris E. (2018). Dynamics and determinants of the force of infection of dengue virus from 1994 to 2015 in Managua, Nicaragua. Proceedings of the National Academy of Sciences of the United States of America, 115(42)

Montoya M, Collins M, Dejnirattisai W, Katzelnick LC, Puerta-Guardo H, Jadi R, Schildhauer S, Supasa P, Vasanawathana S, Malasit P, Mongkolsapaya J, de Silva AD, Tissera H, Balmaseda A, Screaton G, de Silva AM, Harris E. (2018). Longitudinal Analysis of Antibody Cross-neutralization Following Zika Virus and Dengue Virus Infection in Asia and the Americas. The Journal of infectious diseases, 218(4)

Gordon A, Gresh L, Ojeda S, Chowell G, Gonzalez K, Sanchez N, Saborio S, Mercado JC, Kuan G, Balmaseda A, Harris E. (2018). Differences in Transmission and Disease Severity Between 2 Successive Waves of Chikungunya. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(11)

Zambrana JV, Bustos Carrillo F, Burger-Calderon R, Collado D, Sanchez N, Ojeda S, Carey Monterrey J, Plazaola M, Lopez B, Arguello S, Elizondo D, Aviles W, Coloma J, Kuan G, Balmaseda A, Gordon A, Harris E. (2018). Seroprevalence, risk factor, and spatial analyses of Zika virus infection after the 2016 epidemic in Managua, Nicaragua. Proceedings of the National Academy of Sciences of the United States of America, 115(37)

Andrade DV, Harris E. (2018). Recent advances in understanding the adaptive immune response to Zika virus and the effect of previous flavivirus exposure. Virus research

Burger-Calderon R, Gonzalez K, Ojeda S, Zambrana JV, Sanchez N, Cerpas Cruz C, Suazo Laguna H, Bustos F, Plazaola M, Lopez Mercado B, Elizondo D, Arguello S, Carey Monterrey J, Nuñez A, Coloma J, Waggoner JJ, Gordon A, Kuan G, Balmaseda A, Harris E. (2018). Zika virus infection in Nicaraguan households. PLoS neglected tropical diseases, 12(5)

de Silva AM, Harris E. (2018). Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination? The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials. Cold Spring Harbor perspectives in biology, 10(6)

Katzelnick LC, Harris E. (2018). The use of longitudinal cohorts for studies of dengue viral pathogenesis and protection. Current opinion in virology

Gordon A, Tsang TK, Cowling BJ, Kuan G, Ojeda S, Sanchez N, Gresh L, Lopez R, Balmaseda A, Harris E. (2018). Influenza Transmission Dynamics in Urban Households, Managua, Nicaragua, 2012-2014. Emerging infectious diseases, 24(10)

Andrade P, Coloma J, Harris E. (2018). ELISPOT-Based "Multi-Color FluoroSpot" to Study Type-Specific and Cross-Reactive Responses in Memory B Cells after Dengue and Zika Virus Infections. Methods in molecular biology (Clifton, N.J.)

Tan Y, Pickett BE, Shrivastava S, Gresh L, Balmaseda A, Amedeo P, Hu L, Puri V, Fedorova NB, Halpin RA, LaPointe MP, Cone MR, Heberlein-Larson L, Kramer LD, Ciota AT, Gordon A, Shabman RS, Das SR, Harris E. (2018). Differing epidemiological dynamics of Chikungunya virus in the Americas during the 2014-2015 epidemic. PLoS neglected tropical diseases, 12(7)

Balmaseda A, Zambrana JV, Collado D, García N, Saborío S, Elizondo D, Mercado JC, Gonzalez K, Cerpas C, Nuñez A, Corti D, Waggoner JJ, Kuan G, Burger-Calderon R, Harris E. (2018). Comparison of Four Serological Methods and Two Reverse Transcription-PCR Assays for Diagnosis and Surveillance of Zika Virus Infection. Journal of clinical microbiology, 56(3)

Arosteguí J, Ledogar RJ, Coloma J, Hernández-Alvarez C, Suazo-Laguna H, Cárcamo A, Reyes RM, Belli A, Andersson N, Harris E. (2017). The Camino Verde intervention in Nicaragua, 2004-2012. BMC Public Health, 17(Suppl 1)

Andrade DV, Katzelnick LC, Widman DG, Balmaseda A, de Silva AM, Baric RS, Harris E. (2017). Analysis of Individuals from a Dengue-Endemic Region Helps Define the Footprint and Repertoire of Antibodies Targeting Dengue Virus 3 Type-Specific Epitopes. MBio, 8(5)

Katzelnick LC, Gresh L, Halloran ME, Mercado JC, Kuan G, Gordon A, Balmaseda A, Harris E. (2017). Antibody-dependent enhancement of severe dengue disease in humans. Science (New York, N.Y.), 358(6365)

Hertz T, Beatty PR, MacMillen Z, Killingbeck SS, Wang C, Harris E. (2017). Antibody Epitopes Identified in Critical Regions of Dengue Virus Nonstructural 1 Protein in Mouse Vaccination and Natural Human Infections. Journal of immunology (Baltimore, Md. : 1950), 198(10)

Parameswaran P, Wang C, Trivedi SB, Eswarappa M, Montoya M, Balmaseda A, Harris E. (2017). Intrahost Selection Pressures Drive Rapid Dengue Virus Microevolution in Acute Human Infections. Cell host & microbe, 22(3)

Schmid MA, González KN, Shah S, Peña J, Mack M, Talarico LB, Polack FP, Harris E. (2017). Influenza and dengue virus co-infection impairs monocyte recruitment to the lung, increases dengue virus titers, and exacerbates pneumonia. European journal of immunology, 47(3)

Katzelnick LC, Coloma J, Harris E. (2017). Dengue: knowledge gaps, unmet needs, and research priorities. The Lancet. Infectious diseases, 17(3)

Glasner DR, Ratnasiri K, Puerta-Guardo H, Espinosa DA, Beatty PR, Harris E. (2017). Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components. PLoS pathogens, 13(11)

Michlmayr D, Andrade P, Gonzalez K, Balmaseda A, Harris E. (2017). monocytes are the main target of Zika virus infection in peripheral blood mononuclear cells in a paediatric study in Nicaragua. Nature microbiology, 2(11)

Katzelnick LC, Montoya M, Gresh L, Balmaseda A, Harris E. (2016). Neutralizing antibody titers against dengue virus correlate with protection from symptomatic infection in a longitudinal cohort. Proceedings of the National Academy of Sciences of the United States of America, 113(3)

Wang C, Katzelnick LC, Montoya M, Hue KD, Simmons CP, Harris E. (2016). Evolutionarily Successful Asian 1 Dengue Virus 2 Lineages Contain One Substitution in Envelope That Increases Sensitivity to Polyclonal Antibody Neutralization. The Journal of infectious diseases, 213(6)

Kuan G, Ramirez S, Gresh L, Ojeda S, Melendez M, Sanchez N, Collado D, Garcia N, Mercado JC, Gordon A, Balmaseda A, Harris E. (2016). Seroprevalence of Anti-Chikungunya Virus Antibodies in Children and Adults in Managua, Nicaragua, After the First Chikungunya Epidemic, 2014-2015. PLoS neglected tropical diseases, 10(6)

Schmid MA, Glasner DR, Shah S, Michlmayr D, Kramer LD, Harris E. (2016). Mosquito Saliva Increases Endothelial Permeability in the Skin, Immune Cell Migration, and Dengue Pathogenesis during Antibody-Dependent Enhancement. PLoS pathogens, 12(6)

Waggoner JJ, Balmaseda A, Gresh L, Sahoo MK, Montoya M, Wang C, Abeynayake J, Kuan G, Pinsky BA, Harris E. (2016). Homotypic Dengue Virus Reinfections in Nicaraguan Children. The Journal of infectious diseases, 214(7)

Puerta-Guardo H, Glasner DR, Harris E. (2016). Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability. PLoS pathogens, 12(7)

Balmaseda A, Gordon A, Gresh L, Ojeda S, Saborio S, Tellez Y, Sanchez N, Kuan G, Harris E. (2016). Clinical Attack Rate of Chikungunya in a Cohort of Nicaraguan Children. The American journal of tropical medicine and hygiene, 94(2)

Wang C, Saborio S, Gresh L, Eswarappa M, Wu D, Fire A, Parameswaran P, Balmaseda A, Harris E. (2016). Chikungunya Virus Sequences Across the First Epidemic in Nicaragua, 2014-2015. The American journal of tropical medicine and hygiene, 94(2)

Guzman MG, Harris E. (2015). Dengue. Lancet (London, England), 385(9966)

Gordon A, Kuan G, Aviles W, Sanchez N, Ojeda S, Lopez B, Gresh L, Balmaseda A, Harris E. (2015). The Nicaraguan pediatric influenza cohort study: design, methods, use of technology, and compliance. BMC infectious diseases

Beatty PR, Puerta-Guardo H, Killingbeck SS, Glasner DR, Hopkins K, Harris E. (2015). Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination. Science translational medicine, 7(304)

Andersson N, Nava-Aguilera E, Arosteguí J, Morales-Perez A, Suazo-Laguna H, Legorreta-Soberanis J, Hernandez-Alvarez C, Fernandez-Salas I, Paredes-Solís S, Balmaseda A, Cortés-Guzmán AJ, Serrano de Los Santos R, Coloma J, Ledogar RJ, Harris E. (2015). Evidence based community mobilization for dengue prevention in Nicaragua and Mexico (Camino Verde, the Green Way): cluster randomized controlled trial. BMJ (Clinical research ed.)

Biswas HH, Gordon A, Nuñez A, Perez MA, Balmaseda A, Harris E. (2015). Lower Low-Density Lipoprotein Cholesterol Levels Are Associated with Severe Dengue Outcome. PLoS neglected tropical diseases, 9(9)

Fong H, Harris E. (2015). Technology, innovation and health equity. Bulletin of the World Health Organization, 93(7)

Hadjilaou A, Green AM, Coloma J, Harris E. (2015). Single-Cell Analysis of B Cell/Antibody Cross-Reactivity Using a Novel Multicolor FluoroSpot Assay. Journal of immunology (Baltimore, Md. : 1950), 195(7)

Coloma J, Harris E. (2015). Broad and strong: the ultimate antibody to dengue virus. Nature immunology, 16(2)

Lau L, Green AM, Balmaseda A, Harris E. (2015). Antibody avidity following secondary dengue virus type 2 infection across a range of disease severity. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

Green AM, Beatty PR, Hadjilaou A, Harris E. (2014). Innate immunity to dengue virus infection and subversion of antiviral responses. Journal of molecular biology, 426(6)

Schmid MA, Diamond MS, Harris E. (2014). Dendritic cells in dengue virus infection: targets of virus replication and mediators of immunity. Frontiers in immunology

Grange L, Simon-Loriere E, Sakuntabhai A, Gresh L, Paul R, Harris E. (2014). Epidemiological risk factors associated with high global frequency of inapparent dengue virus infections. Frontiers in immunology

Green AM, Harris E. (2014). Monocyte-plasmablast crosstalk during dengue. Cell host & microbe, 16(1)

Schmid MA, Harris E. (2014). Monocyte recruitment to the dermis and differentiation to dendritic cells increases the targets for dengue virus replication. PLoS pathogens, 10(12)

Quiner CA, Parameswaran P, Ciota AT, Ehrbar DJ, Dodson BL, Schlesinger S, Kramer LD, Harris E. (2014). Increased replicative fitness of a dengue virus 2 clade in native mosquitoes: potential contribution to a clade replacement event in Nicaragua. Journal of virology, 88(22)

Zompi S, Harris E. (2013). Original antigenic sin in dengue revisited. Proceedings of the National Academy of Sciences of the United States of America, 110(22)

Gordon A, Kuan G, Mercado JC, Gresh L, Avilés W, Balmaseda A, Harris E. (2013). The Nicaraguan pediatric dengue cohort study: incidence of inapparent and symptomatic dengue virus infections, 2004-2010. PLoS neglected tropical diseases, 7(9)

Gutiérrez G, Gresh L, Pérez MÁ, Elizondo D, Avilés W, Kuan G, Balmaseda A, Harris E. (2013). Evaluation of the diagnostic utility of the traditional and revised WHO dengue case definitions. PLoS neglected tropical diseases, 7(8)

Puschnik A, Lau L, Cromwell EA, Balmaseda A, Zompi S, Harris E. (2013). Correlation between dengue-specific neutralizing antibodies and serum avidity in primary and secondary dengue virus 3 natural infections in humans. PLoS neglected tropical diseases, 7(6)

Montoya M, Gresh L, Mercado JC, Williams KL, Vargas MJ, Gutierrez G, Kuan G, Gordon A, Balmaseda A, Harris E. (2013). Symptomatic versus inapparent outcome in repeat dengue virus infections is influenced by the time interval between infections and study year. PLoS neglected tropical diseases, 7(8)

Williams KL, Sukupolvi-Petty S, Beltramello M, Johnson S, Sallusto F, Lanzavecchia A, Diamond MS, Harris E. (2013). Therapeutic efficacy of antibodies lacking Fcγ receptor binding against lethal dengue virus infection is due to neutralizing potency and blocking of enhancing antibodies [corrected]. PLoS pathogens, 9(2)

Groat-Carmona AM, Orozco S, Friebe P, Payne A, Kramer L, Harris E. (2012). A novel coding-region RNA element modulates infectious dengue virus particle production in both mammalian and mosquito cells and regulates viral replication in Aedes aegypti mosquitoes. Virology, 432(2)

Zompi S, Montoya M, Pohl MO, Balmaseda A, Harris E. (2012). Dominant cross-reactive B cell response during secondary acute dengue virus infection in humans. PLoS neglected tropical diseases, 6(3)

Friebe P, Peña J, Pohl MO, Harris E. (2012). Composition of the sequence downstream of the dengue virus 5' cyclization sequence (dCS) affects viral RNA replication. Virology, 422(2)

Williams KL, Wahala WM, Orozco S, de Silva AM, Harris E. (2012). Antibodies targeting dengue virus envelope domain III are not required for serotype-specific protection or prevention of enhancement in vivo. Virology, 429(1)

Biswas HH, Ortega O, Gordon A, Standish K, Balmaseda A, Kuan G, Harris E. (2012). Early clinical features of dengue virus infection in nicaraguan children: a longitudinal analysis. PLoS neglected tropical diseases, 6(3)

Peña J, Harris E. (2012). Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway. PLoS One, 7(6)

Zompi S, Santich BH, Beatty PR, Harris E. (2012). Protection from secondary dengue virus infection in a mouse model reveals the role of serotype cross-reactive B and T cells. Journal of immunology (Baltimore, Md. : 1950), 188(1)

Orozco S, Schmid MA, Parameswaran P, Lachica R, Henn MR, Beatty R, Harris E. (2012). Characterization of a model of lethal dengue virus 2 infection in C57BL/6 mice deficient in the alpha/beta interferon receptor. The Journal of general virology, 93(Pt 10)

Zompi S, Harris E. (2012). Animal models of dengue virus infection. Viruses, 4(1)

Peña J, Harris E. (2011). Dengue virus modulates the unfolded protein response in a time-dependent manner. The Journal of biological chemistry, 286(16)

OhAinle M, Balmaseda A, Macalalad AR, Tellez Y, Zody MC, Saborío S, Nuñez A, Lennon NJ, Birren BW, Gordon A, Henn MR, Harris E. (2011). Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity. Science translational medicine, 3(114)

Gutierrez G, Standish K, Narvaez F, Perez MA, Saborio S, Elizondo D, Ortega O, Nuñez A, Kuan G, Balmaseda A, Harris E. (2011). Unusual dengue virus 3 epidemic in Nicaragua, 2009. PLoS neglected tropical diseases, 5(11)

Friebe P, Shi PY, Harris E. (2011). The 5' and 3' downstream AUG region elements are required for mosquito-borne flavivirus RNA replication. Journal of virology, 85(4)

Narvaez F, Gutierrez G, Pérez MA, Elizondo D, Nuñez A, Balmaseda A, Harris E. (2011). Evaluation of the traditional and revised WHO classifications of Dengue disease severity. PLoS neglected tropical diseases, 5(11)

Gordon A, Videa E, Saborío S, López R, Kuan G, Balmaseda A, Harris E. (2010). Diagnostic accuracy of a rapid influenza test for pandemic influenza A H1N1. PLoS One, 5(4)

Standish K, Kuan G, Avilés W, Balmaseda A, Harris E. (2010). High dengue case capture rate in four years of a cohort study in Nicaragua compared to national surveillance data. PLoS neglected tropical diseases, 4(3)

Loke P, Hammond SN, Leung JM, Kim CC, Batra S, Rocha C, Balmaseda A, Harris E. (2010). Gene expression patterns of dengue virus-infected children from nicaragua reveal a distinct signature of increased metabolism. PLoS neglected tropical diseases, 4(6)

Balsitis SJ, Williams KL, Lachica R, Flores D, Kyle JL, Mehlhop E, Johnson S, Diamond MS, Beatty PR, Harris E. (2010). Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification. PLoS pathogens, 6(2)

Balmaseda A, Standish K, Mercado JC, Matute JC, Tellez Y, Saborío S, Hammond SN, Nuñez A, Avilés W, Henn MR, Holmes EC, Gordon A, Coloma J, Kuan G, Harris E. (2010). Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua. The Journal of infectious diseases, 201(1)

Friebe P, Harris E. (2010). Interplay of RNA elements in the dengue virus 5' and 3' ends required for viral RNA replication. Journal of virology, 84(12)

Reyes M, Mercado JC, Standish K, Matute JC, Ortega O, Moraga B, Avilés W, Henn MR, Balmaseda A, Kuan G, Harris E. (2010). Index cluster study of dengue virus infection in Nicaragua. The American journal of tropical medicine and hygiene, 83(3)

Paranjape SM, Harris E. (2010). Control of dengue virus translation and replication. Current topics in microbiology and immunology

Gordon A, Saborío S, Videa E, López R, Kuan G, Balmaseda A, Harris E. (2010). Clinical attack rate and presentation of pandemic H1N1 influenza versus seasonal influenza A and B in a pediatric cohort in Nicaragua. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 50(11)

Gordon A, Videa E, Saborio S, López R, Kuan G, Reingold A, Balmaseda A, Harris E. (2009). Performance of an influenza rapid test in children in a primary healthcare setting in Nicaragua. PLoS One, 4(11)

Balsitis SJ, Coloma J, Castro G, Alava A, Flores D, McKerrow JH, Beatty PR, Harris E. (2009). Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. The American journal of tropical medicine and hygiene, 80(3)

Kuan G, Gordon A, Avilés W, Ortega O, Hammond SN, Elizondo D, Nuñez A, Coloma J, Balmaseda A, Harris E. (2009). The Nicaraguan pediatric dengue cohort study: study design, methods, use of information technology, and extension to other infectious diseases. American journal of epidemiology, 170(1)

Gordon A, Ortega O, Kuan G, Reingold A, Saborio S, Balmaseda A, Harris E. (2009). Prevalence and seasonality of influenza-like illness in children, Nicaragua, 2005-2007. Emerging infectious diseases, 15(3)

Polacek C, Friebe P, Harris E. (2009). Poly(A)-binding protein binds to the non-polyadenylated 3' untranslated region of dengue virus and modulates translation efficiency. The Journal of general virology, 90(Pt 3)

Coloma J, Harris E. (2009). Molecular genomic approaches to infectious diseases in resource-limited settings. PLoS medicine, 6(10)

Rocha C, Silva S, Gordon A, Hammond SN, Elizondo D, Balmaseda A, Harris E. (2009). Improvement in hospital indicators after changes in dengue case management in Nicaragua. The American journal of tropical medicine and hygiene, 81(2)

Coloma J, Harris E. (2009). From construction workers to architects: developing scientific research capacity in low-income countries. PLoS biology, 7(7)

Polacek C, Foley JE, Harris E. (2009). Conformational changes in the solution structure of the dengue virus 5' end in the presence and absence of the 3' untranslated region. Journal of virology, 83(2)

Williams KL, Zompi S, Beatty PR, Harris E. (2009). A mouse model for studying dengue virus pathogenesis and immune response. Annals of the New York Academy of Sciences

Clyde K, Barrera J, Harris E. (2008). The capsid-coding region hairpin element (cHP) is a critical determinant of dengue virus and West Nile virus RNA synthesis. Virology, 379(2)

Kyle JL, Balsitis SJ, Zhang L, Beatty PR, Harris E. (2008). Antibodies play a greater role than immune cells in heterologous protection against secondary dengue virus infection in a mouse model. Virology, 380(2)

Durbin AP, Vargas MJ, Wanionek K, Hammond SN, Gordon A, Rocha C, Balmaseda A, Harris E. (2008). Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever. Virology, 376(2)

Avilés W, Ortega O, Kuan G, Coloma J, Harris E. (2008). Quantitative assessment of the benefits of specific information technologies applied to clinical studies in developing countries. The American journal of tropical medicine and hygiene, 78(2)

Kyle JL, Harris E. (2008). Global spread and persistence of dengue. Annual review of microbiology

Balmaseda A, Saborio S, Tellez Y, Mercado JC, Pérez L, Hammond SN, Rocha C, Kuan G, Harris E. (2008). Evaluation of immunological markers in serum, filter-paper blood spots, and saliva for dengue diagnosis and epidemiological studies. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 43(3)

Coloma J, Harris E. (2007). Sustainable transfer of biotechnology to developing countries: fighting poverty by bringing scientific tools to developing-country partners. Annals of the New York Academy of Sciences

Paranjape SM, Harris E. (2007). Y box-binding protein-1 binds to the dengue virus 3'-untranslated region and mediates antiviral effects. The Journal of biological chemistry, 282(42)

Kyle JL, Beatty PR, Harris E. (2007). Dengue virus infects macrophages and dendritic cells in a mouse model of infection. The Journal of infectious diseases, 195(12)

Colbert JA, Gordon A, Roxelin R, Silva S, Silva J, Rocha C, Harris E. (2007). Ultrasound measurement of gallbladder wall thickening as a diagnostic test and prognostic indicator for severe dengue in pediatric patients. The Pediatric infectious disease journal, 26(9)

Harris E. (2007). Straight talk from... Eva Harris. Nature medicine, 13(10)

Avilés W, Ortega O, Kuan G, Coloma J, Harris E. (2007). Integration of information technologies in clinical studies in Nicaragua. PLoS medicine, 4(10)

Hammond SN, Gordon AL, Lugo Edel C, Moreno G, Kuan GM, López MM, López JD, Delgado MA, Valle SI, Espinoza PM, Harris E. (2007). Characterization of Aedes aegypti (Diptera: Culcidae) production sites in urban Nicaragua. Journal of medical entomology, 44(5)

Holden KL, Stein DA, Pierson TC, Ahmed AA, Clyde K, Iversen PL, Harris E. (2006). Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure. Virology, 344(2)

Balmaseda A, Hammond SN, Pérez L, Tellez Y, Saborío SI, Mercado JC, Cuadra R, Rocha J, Pérez MA, Silva S, Rocha C, Harris E. (2006). Serotype-specific differences in clinical manifestations of dengue. The American journal of tropical medicine and hygiene, 74(3)

Clyde K, Kyle JL, Harris E. (2006). Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis. Journal of virology, 80(23)

Clyde K, Harris E. (2006). RNA secondary structure in the coding region of dengue virus type 2 directs translation start codon selection and is required for viral replication. Journal of virology, 80(5)

Shresta S, Sharar KL, Prigozhin DM, Beatty PR, Harris E. (2006). Murine model for dengue virus-induced lethal disease with increased vascular permeability. Journal of virology, 80(20)

Harris E, Holden KL, Edgil D, Polacek C, Clyde K. (2006). Molecular biology of flaviviruses. Novartis Foundation symposium

Balmaseda A, Hammond SN, Tellez Y, Imhoff L, Rodriguez Y, Saborío SI, Mercado JC, Perez L, Videa E, Almanza E, Kuan G, Reyes M, Saenz L, Amador JJ, Harris E. (2006). High seroprevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua. Tropical medicine & international health : TM & IH, 11(6)

Edgil D, Harris E. (2006). End-to-end communication in the modulation of translation by mammalian RNA viruses. Virus research, 119(1)

Edgil D, Polacek C, Harris E. (2006). Dengue virus utilizes a novel strategy for translation initiation when cap-dependent translation is inhibited. Journal of virology, 80(6)

Shresta S, Sharar KL, Prigozhin DM, Snider HM, Beatty PR, Harris E. (2005). Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice. Journal of immunology (Baltimore, Md. : 1950), 175(6)

Balmaseda A, Hammond SN, Pérez MA, Cuadra R, Solano S, Rocha J, Idiaquez W, Harris E. (2005). Short report: assessment of the World Health Organization scheme for classification of dengue severity in Nicaragua. The American journal of tropical medicine and hygiene, 73(6)

Helt AM, Harris E. (2005). S-phase-dependent enhancement of dengue virus 2 replication in mosquito cells, but not in human cells. Journal of virology, 79(21)

Coloma J, Harris E. (2005). Open-access science: a necessity for global public health. PLoS pathogens, 1(2)

Videa E, Coloma MJ, Dos Santos FB, Balmaseda A, Harris E. (2005). Immunoglobulin M enzyme-linked immunosorbent assay using recombinant polypeptides for diagnosis of dengue. Clinical and diagnostic laboratory immunology, 12(7)

Lugo Edel C, Moreno G, Zachariah MA, López MM, López JD, Delgado MA, Valle SI, Espinoza PM, Salgado MJ, Pérez R, Hammond SN, Harris E. (2005). Identification of Aedes albopictus in urban Nicaragua. Journal of the American Mosquito Control Association, 21(3)

Hammond SN, Balmaseda A, Pérez L, Tellez Y, Saborío SI, Mercado JC, Videa E, Rodriguez Y, Pérez MA, Cuadra R, Solano S, Rocha J, Idiaquez W, Gonzalez A, Harris E. (2005). Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua. The American journal of tropical medicine and hygiene, 73(6)

Shresta S, Kyle JL, Robert Beatty P, Harris E. (2004). Early activation of natural killer and B cells in response to primary dengue virus infection in A/J mice. Virology, 319(2)

Coloma J, Harris E. (2004). Innovative low cost technologies for biomedical research and diagnosis in developing countries. BMJ (Clinical research ed.), 329(7475)

Holden KL, Harris E. (2004). Enhancement of dengue virus translation: role of the 3' untranslated region and the terminal 3' stem-loop domain. Virology, 329(1)

Shresta S, Kyle JL, Snider HM, Basavapatna M, Beatty PR, Harris E. (2004). Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less critical. Journal of virology, 78(6)

Harris E. (2004). Building scientific capacity in developing countries. EMBO reports, 5(1)

dos Santos FB, Miagostovich MP, Nogueira RM, Schatzmayr HG, Riley LW, Harris E. (2004). Analysis of recombinant dengue virus polypeptides for dengue diagnosis and evaluation of the humoral immune response. The American journal of tropical medicine and hygiene, 71(2)

Edgil D, Diamond MS, Holden KL, Paranjape SM, Harris E. (2003). Translation efficiency determines differences in cellular infection among dengue virus type 2 strains. Virology, 317(2)

Harris E, Pérez L, Phares CR, Pérez Mde L, Idiaquez W, Rocha J, Cuadra R, Hernandez E, Campos LA, Gonzales A, Amador JJ, Balmaseda A. (2003). Fluid intake and decreased risk for hospitalization for dengue fever, Nicaragua. Emerging infectious diseases, 9(8)

Balmaseda A, Guzmán MG, Hammond S, Robleto G, Flores C, Téllez Y, Videa E, Saborio S, Pérez L, Sandoval E, Rodriguez Y, Harris E. (2003). Diagnosis of dengue virus infection by detection of specific immunoglobulin M (IgM) and IgA antibodies in serum and saliva. Clinical and diagnostic laboratory immunology, 10(2)

Diamond MS, Zachariah M, Harris E. (2002). Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA. Virology, 304(2)

dos Santos FB, Miagostovich MP, Nogueira RM, Edgil D, Schatzmayr HG, Riley LW, Harris E. (2002). Complete nucleotide sequence analysis of a Brazilian dengue virus type 2 strain. Memorias do Instituto Oswaldo Cruz, 97(7)