Dr. Filippo Castiglione is a computer scientist interested in the application of modelling and simulation as well as machine learning techniques to biology and medicine. He is Executive Director of the Bioinformatics section in the Biotech Research Center of the Technology Innovation Institute of Abu Dhabi, UAE.
He/him/his
United States
United Arab Emirates
Netherlands
Italy
Gabellieri F, Singh A, Gupta S, Bensmail H, Castiglione F, Mall R. (2026). B-cell epitope prediction in the age of machine learning: advancements and challenges. Journal of translational medicine
Al Shareef ZM, Al-Shahrabi RM, Sharif-Askari FS, Yener B, Bhamidimarri PM, Bouzid A, Talaat IM, Bendardaf R, Hamoudi RA, Mote S, Mall R, Castiglione F. (2026). Microbial dysbiosis and inferred functional profiling reveals the potential role of Methylobacterium in prostate cancer. Frontiers in cellular and infection microbiology, (16)
Castorina P, Castiglione F, Ferini G, Forte S, Martorana E. (2025). Quantitative Method for Monitoring Tumor Evolution During and After Therapy. Journal of personalized medicine, 15(7)
Ravoni A, Mastrostefano E, Kappler R, Armengol C, Castiglione F, Nardini C. (2025). Mimicking cancer therapy in an agent-based model: The case of hepatoblastoma. Computer methods and programs in biomedicine, (269)
Mall R, Kaushik R, Martinez ZA, Thomson MW, Castiglione F. (2025). Benchmarking protein language models for protein crystallization. Scientific reports, 15(1)
Mall R, Singh A, Patel CN, Guirimand G, Castiglione F. (2024). VISH-Pred: an ensemble of fine-tuned ESM models for protein toxicity prediction. Briefings in bioinformatics, 25(4)
Castorina P, Castiglione F, Ferini G, Forte S, Martorana E. (2024). Computational Approach for Spatially Fractionated Radiation Therapy (SFRT) and Immunological Response in Precision Radiation Therapy. Journal of personalized medicine, 14(4)
Laubenbacher R, Adler F, An G, Castiglione F, Eubank S, Fonseca LL, Glazier J, Helikar T, Jett-Tilton M, Kirschner D, Macklin P, Mehrad B, Moore B, Pasour V, Shmulevich I, Smith A, Voigt I, Yankeelov TE, Ziemssen T. (2024). Forum on immune digital twins: a meeting report. NPJ systems biology and applications, 10(1)
Yousef H, Malagurski Tortei B, Castiglione F. (2024). Predicting multiple sclerosis disease progression and outcomes with machine learning and MRI-based biomarkers: a review. Journal of neurology
Castorina P, Castiglione F, Ferini G, Forte S, Martorana E, Giuffrida D. (2024). Mathematical modeling of the synergistic interplay of radiotherapy and immunotherapy in anti-cancer treatments. Frontiers in immunology, (15)
Laubenbacher R, Adler F, An G, Castiglione F, Eubank S, Fonseca LL, Glazier J, Helikar T, Jett-Tilton M, Kirschner D, Macklin P, Mehrad B, Moore B, Pasour V, Shmulevich I, Smith A, Voigt I, Yankeelov TE, Ziemssen T. (2024). Toward mechanistic medical digital twins: some use cases in immunology. Frontiers in digital health, (6)
Uleman JF, Mancini E, Al-Shama RFM, Te Velde AA, Kraneveld AD, Castiglione F. (2023). A multiscale hybrid model for exploring the effect of Resolvin D1 on macrophage polarization during acute inflammation. Mathematical biosciences, (359)
Palumbo MC, de Graaf AA, Morettini M, Tieri P, Krishnan S, Castiglione F. (2023). A computational model of the effects of macronutrients absorption and physical exercise on hormonal regulation and metabolic homeostasis. Computers in biology and medicine, (163)
Stolfi P, Castiglione F, Mastrostefano E, Di Biase I, Di Biase S, Palmieri G, Prisco A. (2022). In-silico evaluation of adenoviral COVID-19 vaccination protocols: Assessment of immunological memory up to 6 months after the third dose. Frontiers in immunology, (13)
Stolfi P, Castiglione F. (2021). Emulating complex simulations by machine learning methods. BMC bioinformatics, 22(Suppl 14)
Basak S, Deb D, Narsaria U, Kar T, Castiglione F, Sanyal I, Bade PD, Srivastava AP. (2021). In silico designing of vaccine candidate against Clostridium difficile. Scientific reports, 11(1)
Castiglione F, Deb D, Srivastava AP, Liò P, Liso A. (2021). From Infection to Immunity: Understanding the Response to SARS-CoV2 Through In-Silico Modeling. Frontiers in immunology, (12)
Deb D, Basak S, Kar T, Narsaria U, Castiglione F, Paul A, Pandey A, Srivastava AP. (2021). Immunoinformatics based designing a multi-epitope vaccine against pathogenic Chandipura vesiculovirus. Journal of cellular biochemistry
Wang H, Pujos-Guillot E, Comte B, de Miranda JL, Spiwok V, Chorbev I, Castiglione F, Tieri P, Watterson S, McAllister R, de Melo Malaquias T, Zanin M, Rai TS, Zheng H. (2021). Deep learning in systems medicine. Briefings in bioinformatics, 22(2)
Stolfi P, Valentini I, Palumbo MC, Tieri P, Grignolio A, Castiglione F. (2020). Potential predictors of type-2 diabetes risk: machine learning, synthetic data and wearable health devices. BMC bioinformatics, 21(Suppl 17)
Kar T, Narsaria U, Basak S, Deb D, Castiglione F, Mueller DM, Srivastava AP. (2020). A candidate multi-epitope vaccine against SARS-CoV-2. Scientific reports, 10(1)
Presbitero A, Mancini E, Castiglione F, Krzhizhanovskaya VV, Quax R. (2019). Game of neutrophils: modeling the balance between apoptosis and necrosis. BMC bioinformatics, 20(Suppl 6)
Castiglione F, Ghersi D, Celada F. (2019). Computer Modeling of Clonal Dominance: Memory-Anti-Naïve and Its Curbing by Attrition. Frontiers in immunology, (10)
Palumbo MC, Morettini M, Tieri P, Diele F, Sacchetti M, Castiglione F. (2018). Personalizing physical exercise in a computational model of fuel homeostasis. PLoS computational biology, 14(4)
Palma A, Jarrah AS, Tieri P, Cesareni G, Castiglione F. (2018). Gene Regulatory Network Modeling of Macrophage Differentiation Corroborates the Continuum Hypothesis of Polarization States. Frontiers in physiology, (9)
Liso A, Castellani S, Massenzio F, Trotta R, Pucciarini A, Bigerna B, De Luca P, Zoppoli P, Castiglione F, Palumbo MC, Stracci F, Landriscina M, Specchia G, Bach LA, Conese M, Falini B. (2017). Human monocyte-derived dendritic cells exposed to hyperthermia show a distinct gene expression profile and selective upregulation of IGFBP6. Oncotarget, 8(37)
Morettini M, Palumbo MC, Sacchetti M, Castiglione F, Mazzà C. (2017). A system model of the effects of exercise on plasma Interleukin-6 dynamics in healthy individuals: Role of skeletal muscle and adipose tissue. PloS one, 12(7)
Castiglione F, Tieri P, Palma A, Jarrah AS. (2016). Statistical ensemble of gene regulatory networks of macrophage differentiation. BMC bioinformatics, 17(Suppl 19)
Cappuccio A, Tieri P, Castiglione F. (2016). Multiscale modelling in immunology: a review. Briefings in bioinformatics, 17(3)
Castiglione F, Pappalardo F, Bianca C, Russo G, Motta S. (2014). Modeling biology spanning different scales: an open challenge. BioMed research international, (2014)
Jarrah AS, Castiglione F, Evans NP, Grange RW, Laubenbacher R. (2014). A mathematical model of skeletal muscle disease and immune response in the mdx mouse. BioMed research international, (2014)
Castiglione F, Diaz V, Gaggioli A, Liò P, Mazzà C, Merelli E, Meskers CG, Pappalardo F, von Ammon R. (2013). Physio-environmental sensing and live modeling. Interactive journal of medical research, 2(1)
Castiglione F, Paci P. (2010). Criticality of timing for anti-HIV therapy initiation. PloS one, 5(12)
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