Howard Chang

Associate Professor




Preferred Pronouns

Personal Academic Website

Research/Topics of Interest

Pathogens/Diseases of Main Interest/Expertise


Countries of Work/Collaboration



Cheng Q, Collender PA, Heaney AK, McLoughlin A, Yang Y, Zhang Y, Head JR, Dasan R, Liang S, Lv Q, Liu Y, Yang C, Chang HH, Waller LA, Zelner J, Lewnard JA, Remais JV. (2022). Optimizing laboratory-based surveillance networks for monitoring multi-genotype or multi-serotype infections. PLoS computational biology, 18(9)

Li Z, Sarnat JA, Liu KH, Hood RB, Chang CJ, Hu X, Tran V, Greenwald R, Chang HH, Russell A, Yu T, Jones DP, Liang D. (2022). Evaluation of the Use of Saliva Metabolome as a Surrogate of Blood Metabolome in Assessing Internal Exposures to Traffic-Related Air Pollution. Environmental science & technology

Li J, Wang Y, Steenland K, Liu P, van Donkelaar A, Martin RV, Chang HH, Caudle WM, Schwartz J, Koutrakis P, Shi L. (2022). components on incident dementia in the northeastern United States. Innovation (New York, N.Y.), 3(2)

Couture A, Iuliano D, Chang H, Patel N, Gilmer M, Steele M, Havers F, Whitaker M, Reed C. (2022). Estimating COVID-19 Hospitalizations in the United States with Surveillance Data Using a Bayesian Hierarchical Model: A Modeling Study. JMIR public health and surveillance

Zhang Y, Chang HH, Cheng Q, Collender PA, Li T, He J, Remais JV. (2022). A hierarchical model for analyzing multi-site individual-level disease surveillance data from multiple systems. Biometrics

Ebelt ST, D'Souza RR, Yu H, Scovronick N, Moss S, Chang HH. (2022). Monitoring vs. modeled exposure data in time-series studies of ambient air pollution and acute health outcomes. Journal of exposure science & environmental epidemiology

Comess S, Chang HH, Warren JL. (2022). A Bayesian framework for incorporating exposure uncertainty into health analyses with application to air pollution and stillbirth. Biostatistics (Oxford, England)

Bailey MJ, Holzhausen EA, Morgan ZEM, Naik N, Shaffer JP, Liang D, Chang HH, Sarnat J, Sun S, Berger PK, Schmidt KA, Lurmann F, Goran MI, Alderete TL. Postnatal exposure to ambient air pollutants is associated with the composition of the infant gut microbiota at 6-months of age. Gut microbes, 14(1)

Richards M, Huang M, Strickland MJ, Newman AJ, Warren JL, D'Souza R, Chang HH, Darrow LA. (2022). Acute association between heatwaves and stillbirth in six US states. Environmental health : a global access science source, 21(1)

Sclar GD, Bauza V, Mosler HJ, Bisoyi A, Chang HH, Clasen TF. (2022). Study design and rationale for a cluster randomized trial of a safe child feces management intervention in rural Odisha, India. BMC public health, 22(1)

Deng X, Brotzge J, Tracy M, Chang HH, Romeiko X, Zhang W, Ryan I, Yu F, Qu Y, Luo G, Lin S. (2022). Identifying joint impacts of sun radiation, temperature, humidity, and rain duration on triggering mental disorders using a high-resolution weather monitoring system. Environment international, (167)

Haque S, Kirby MA, Iyakaremye L, Gebremariam A, Tessema G, Thomas E, Chang HH, Clasen T. (2022). Effects of adding household water filters to Rwanda's Community-Based Environmental Health Promotion Programme: a cluster-randomized controlled trial in Rwamagana district. NPJ clean water, 5(1)

Clasen TF, Chang HH, Thompson LM, Kirby MA, Balakrishnan K, Díaz-Artiga A, McCracken JP, Rosa G, Steenland K, Younger A, Aravindalochanan V, Barr DB, Castañaza A, Chen Y, Chiang M, Clark ML, Garg S, Hartinger S, Jabbarzadeh S, Johnson MA, Kim DY, Lovvorn AE, McCollum ED, Monroy L, Moulton LH, Mukeshimana A, Mukhopadhyay K, Naeher LP, Ndagijimana F, Papageorghiou A, Piedrahita R, Pillarisetti A, Puttaswamy N, Quinn A, Ramakrishnan U, Sambandam S, Sinharoy SS, Thangavel G, Underhill LJ, Waller LA, Wang J, Williams KN, Rosenthal JP, Checkley W, Peel JL, . (2022). Liquefied Petroleum Gas or Biomass for Cooking and Effects on Birth Weight. The New England journal of medicine

Mahgoub U, Magee MJ, Heydari M, Choudhary M, Santamarina G, Schenker M, Rajani R, Umpierrez GE, Fayfman M, Chang HH, Schechter MC. (2022). Outpatient clinic attendance and outcomes among patients hospitalized with diabetic foot ulcers. Journal of diabetes and its complications, 36(10)

Qu Y, Deng X, Lin S, Han F, Chang HH, Ou Y, Nie Z, Mai J, Wang X, Gao X, Wu Y, Chen J, Zhuang J, Ryan I, Liu X. (2022). Using Innovative Machine Learning Methods to Screen and Identify Predictors of Congenital Heart Diseases. Frontiers in cardiovascular medicine, (8)

Zhang Y, Chang HH, Iuliano AD, Reed C. (2022). Application of Bayesian spatial-temporal models for estimating unrecognized COVID-19 deaths in the United States. Spatial statistics

Johnson M, Pillarisetti A, Piedrahita R, Balakrishnan K, Peel JL, Steenland K, Underhill LJ, Rosa G, Kirby MA, Díaz-Artiga A, McCracken J, Clark ML, Waller L, Chang HH, Wang J, Dusabimana E, Ndagijimana F, Sambandam S, Mukhopadhyay K, Kearns KA, Campbell D, Kremer J, Rosenthal JP, Checkley W, Clasen T, Naeher L, . (2022). Exposure Contrasts of Pregnant Women during the Household Air Pollution Intervention Network Randomized Controlled Trial. Environmental health perspectives, 130(9)

Jiang S, Warren JL, Scovronick N, Moss SE, Darrow LA, Strickland MJ, Newman AJ, Chen Y, Ebelt ST, Chang HH. (2021). Using logic regression to characterize extreme heat exposures and their health associations: a time-series study of emergency department visits in Atlanta. BMC medical research methodology, 21(1)

Zhang Y, Shi L, Chang H, Schwartz J, Di Q, Goldberg J, Vaccarino V. (2021). A Co-Twin control study of fine particulate matter and the prevalence of metabolic syndrome risk factors. Environmental research

Huang M, Strickland MJ, Richards M, Holmes HA, Newman AJ, Garn JV, Liu Y, Warren JL, Chang HH, Darrow LA. (2021). Acute associations between heatwaves and preterm and early-term birth in 50 US metropolitan areas: a matched case-control study. Environmental health : a global access science source, 20(1)

Shi L, Rosenberg A, Wang Y, Liu P, Danesh Yazdi M, Réquia W, Steenland K, Chang H, Sarnat JA, Wang W, Zhang K, Zhao J, Schwartz J. (2021). Low-Concentration Air Pollution and Mortality in American Older Adults: A National Cohort Analysis (2001-2017). Environmental science & technology

Sun YV, Liu C, Staimez L, Ali MK, Chang H, Kondal D, Patel S, Jones D, Mohan V, Tandon N, Prabhakaran D, Quyyumi AA, Narayan KMV, Agrawal A. (2021). Cardiovascular disease risk and pathophysiology in South Asians: can longitudinal multi-omics shed light?. Wellcome open research, (5)

Shi L, Steenland K, Li H, Liu P, Zhang Y, Lyles RH, Requia WJ, Ilango SD, Chang HH, Wingo T, Weber RJ, Schwartz J. (2021). A national cohort study (2000-2018) of long-term air pollution exposure and incident dementia in older adults in the United States. Nature communications, 12(1)

Qian W, Chang HH. (2021). Projecting Health Impacts of Future Temperature: A Comparison of Quantile-Mapping Bias-Correction Methods. International journal of environmental research and public health, 18(4)

Iuliano AD, Chang HH, Patel NN, Threlkel R, Kniss K, Reich J, Steele M, Hall AJ, Fry AM, Reed C. (2021). Estimating Under-recognized COVID-19 Deaths, United States, March 2020-May 2021 using an Excess Mortality Modelling Approach. Lancet Regional Health. Americas

Dharmalingam S, Senthilkumar N, D'Souza RR, Hu Y, Chang HH, Ebelt S, Yu H, Kim CS, Rohr A. (2021). Developing air pollution concentration fields for health studies using multiple methods: Cross-comparison and evaluation. Environmental research

Wise A, Kianian B, Chang HH, Linton S, Wolfe ME, Smith J, Tempalski B, Jarlais DD, Ross Z, Semaan S, Wejnert C, Broz D, Cooper HLF. (2021). Is the severity of the Great Recession's aftershocks correlated with changes in access to the combined prevention environment among people who inject drugs?. The International journal on drug policy, (95)

Sinharoy SS, Reese HE, Praharaj I, Chang HH, Clasen T. (2021). Effects of a combined water and sanitation intervention on biomarkers of child environmental enteric dysfunction and associations with height-for-age z-score: A matched cohort study in rural Odisha, India. PLoS neglected tropical diseases, 15(3)

Thomas N, Ebelt ST, Newman AJ, Scovronick N, D'Souza RR, Moss SE, Warren JL, Strickland MJ, Darrow LA, Chang HH. (2021). Time-series analysis of daily ambient temperature and emergency department visits in five US cities with a comparison of exposure metrics derived from 1-km meteorology products. Environmental health : a global access science source, 20(1)

Wang Y, Xiao S, Zhang Y, Chang H, Martin RV, Van Donkelaar A, Gaskins A, Liu Y, Liu P, Shi L. (2021). major components and mortality in the southeastern United States. Environment international, (158)

Bi J, Barry V, Weil EJ, Chang HH, Ebelt S. (2021). Short-term exposure to fine particulate air pollution and emergency department visits for kidney diseases in the Atlanta metropolitan area. Environmental epidemiology (Philadelphia, Pa.), 5(4)

Wise A, Kianian B, Chang H, Linton S, Wolfe ME, Smith J, Tempalski B, Des Jarlais D, Ross Z, Semaan S, Wejnert C, Broz D, Cooper H. (2021). Place-Based Correlates of Exchange Sex Among People Who Inject Drugs in 19 U.S. Metropolitan Areas, 2012. Archives of sexual behavior

Gong W, Reich BJ, Chang HH. (2021). Multivariate Spatial Prediction of Air Pollutant Concentrations with INLA. Environmental research communications, 3(10)

Wu HJ, Wen-Wei Ku S, Chang HH, Li CW, Ko NY, Strong C. (2021). Imperfect adherence in real life: a prevention-effective perspective on adherence to daily and event-driven HIV pre-exposure prophylaxis among men who have sex with men - a prospective cohort study in Taiwan. Journal of the International AIDS Society, 24(5)

Liang D, Shi L, Zhao J, Liu P, Sarnat JA, Gao S, Schwartz J, Liu Y, Ebelt ST, Scovronick N, Chang HH. (2020). Urban Air Pollution May Enhance COVID-19 Case-Fatality and Mortality Rates in the United States. Innovation (New York, N.Y.), 1(3)

Dawood FS, Kittikraisak W, Patel A, Rentz Hunt D, Suntarattiwong P, Wesley MG, Thompson MG, Soto G, Mundhada S, Arriola CS, Azziz-Baumgartner E, Brummer T, Cabrera S, Chang HH, Deshmukh M, Ellison D, Florian R, Gonzales O, Kurhe K, Kaoiean S, Rawangban B, Lindstrom S, Llajaruna E, Mott JA, Saha S, Prakash A, Mohanty S, Sinthuwattanawibool C, Tinoco Y. (2020). Incidence of influenza during pregnancy and association with pregnancy and perinatal outcomes in three middle-income countries: a multisite prospective longitudinal cohort study. The Lancet. Infectious diseases

Deshpande A, Chang HH, Levy K. (2020). Heavy Rainfall Events and Diarrheal Diseases: The Role of Urban-Rural Geography. The American journal of tropical medicine and hygiene, 103(3)

Li Z, Liang D, Ye D, Chang HH, Ziegler TR, Jones DP, Ebelt ST. (2020). Application of high-resolution metabolomics to identify biological pathways perturbed by traffic-related air pollution. Environmental research, (193)

Kalia V, Schuur SS, Hobson KA, Chang HH, Waller LA, Hare SR, Gribble MO. (2020). Relationship between the Pacific Decadal Oscillation (PDO) and persistent organic pollutants in sympatric Alaskan seabird (Uria aalge and U. lomvia) eggs between 1999 and 2010. Chemosphere, (262)

Bi J, D'Souza RR, Rich DQ, Hopke PK, Russell AG, Liu Y, Chang HH, Ebelt S. (2020). in Los Angeles, 2005 to 2016. Environmental research, (190)

Bi J, Wildani A, Chang HH, Liu Y. (2020). Modeling at a Large Spatial Scale. Environmental science & technology, 54(4)

Naser AM, Doza S, Rahman M, Unicomb L, Ahmed KM, Anand S, Selim S, Shamsudduha M, Narayan KMV, Chang H, Clasen TF, Gribble MO, Luby SP. (2020). Consequences of access to water from managed aquifer recharge systems for blood pressure and proteinuria in south-west coastal Bangladesh: a stepped-wedge cluster-randomized trial. International journal of epidemiology

Cozza V, Campbell H, Chang HH, Iuliano AD, Paget J, Patel NN, Reiner RC, Troeger C, Viboud C, Bresee JS, Fitzner J. (2020). Global seasonal influenza mortality estimates: a comparison of three different approaches. American journal of epidemiology

Chard AN, Levy K, Baker KK, Tsai K, Chang HH, Thongpaseuth V, Sistrunk JR, Freeman MC. (2020). Environmental and spatial determinants of enteric pathogen infection in rural Lao People's Democratic Republic: A cross-sectional study. PLoS neglected tropical diseases, 14(4)

Liang D, Shi L, Zhao J, Liu P, Schwartz J, Gao S, Sarnat J, Liu Y, Ebelt S, Scovronick N, Chang HH. (2020). Urban Air Pollution May Enhance COVID-19 Case-Fatality and Mortality Rates in the United States. medRxiv : the preprint server for health sciences

Duan R, Luo C, Schuemie MJ, Tong J, Liang CJ, Chang HH, Boland MR, Bian J, Xu H, Holmes JH, Forrest CB, Morton SC, Berlin JA, Moore JH, Mahoney KB, Chen Y. (2020). Learning from local to global: An efficient distributed algorithm for modeling time-to-event data. Journal of the American Medical Informatics Association : JAMIA

Cheng Q, Collender PA, Heaney AK, Li X, Dasan R, Li C, Lewnard JA, Zelner JL, Liang S, Chang HH, Waller LA, Lopman BA, Yang C, Remais JV. (2020). The DIOS framework for optimizing infectious disease surveillance: Numerical methods for simulation and multi-objective optimization of surveillance network architectures. PLoS computational biology, 16(12)

Berrocal VJ, Guan Y, Muyskens A, Wang H, Reich BJ, Mulholland JA, Chang HH. (2020). concentration. Atmospheric environment (Oxford, England : 1994), (222)

Goddard FGB, Pickering AJ, Ercumen A, Brown J, Chang HH, Clasen T. (2020). Faecal contamination of the environment and child health: a systematic review and individual participant data meta-analysis. The Lancet. Planetary health, 4(9)

Clasen T, Checkley W, Peel JL, Balakrishnan K, McCracken JP, Rosa G, Thompson LM, Barr DB, Clark ML, Johnson MA, Waller LA, Jaacks LM, Steenland K, Miranda JJ, Chang HH, Kim DY, McCollum ED, Davila-Roman VG, Papageorghiou A, Rosenthal JP,. (2020). Design and Rationale of the HAPIN Study: A Multicountry Randomized Controlled Trial to Assess the Effect of Liquefied Petroleum Gas Stove and Continuous Fuel Distribution. Environmental health perspectives, 128(4)

Warren JL, Luben TJ, Chang HH. (2020). A spatially varying distributed lag model with application to an air pollution and term low birth weight study. Journal of the Royal Statistical Society. Series C, Applied statistics, 69(3)

Li X, Chang HH, Cheng Q, Collender PA, Li T, He J, Waller LA, Lopman BA, Remais JV. (2020). A spatial hierarchical model for integrating and bias-correcting data from passive and active disease surveillance systems. Spatial and spatio-temporal epidemiology, (35)

Zhang T, Geng G, Liu Y, Chang HH. (2020). Components. Atmosphere, 11(11)

Murray NL, Holmes HA, Liu Y, Chang HH. (2019). A Bayesian ensemble approach to combine PM2.5 estimates from statistical models using satellite imagery and numerical model simulation. Environmental research, (178)

Levy MC, Collender PA, Carlton EJ, Chang HH, Strickland MJ, Eisenberg JNS, Remais JV. (2019). Spatiotemporal Error in Rainfall Data: Consequences for Epidemiologic Analysis of Waterborne Diseases. American journal of epidemiology, 188(5)

Chang HH, Pan A, Lary DJ, Waller LA, Zhang L, Brackin BT, Finley RW, Faruque FS. (2019). Time-series analysis of satellite-derived fine particulate matter pollution and asthma morbidity in Jackson, MS. Environmental monitoring and assessment, 191(Suppl 2)

Collender PA, Morris C, Glenn-Finer R, Acevedo A, Chang HH, Trostle JA, Eisenberg JNS, Remais JV. (2019). Mass Gatherings and Diarrheal Disease Transmission among Rural Communities in Coastal Ecuador. American journal of epidemiology, 188(8)

Murray NL, Holmes HA, Liu Y, Chang HH. (2020). estimates from statistical models using satellite imagery and numerical model simulation"[Environ. Res. 178 (2019) 108601]. Environmental research, (183)

Warren JL, Kong W, Luben TJ, Chang HH. (2019). Critical window variable selection: estimating the impact of air pollution on very preterm birth. Biostatistics (Oxford, England)

Strickland MJ, Lin Y, Darrow LA, Warren JL, Mulholland JA, Chang HH. (2019). Associations Between Ambient Air Pollutant Concentrations and Birth Weight: A Quantile Regression Analysis. Epidemiology (Cambridge, Mass.), 30(5)

Cucchi K, Liu R, Collender PA, Cheng Q, Li C, Hoover CM, Chang HH, Liang S, Yang C, Remais JV. (2019). Hydroclimatic drivers of highly seasonal leptospirosis incidence suggest prominent soil reservoir of pathogenic Leptospira spp. in rural western China. PLoS neglected tropical diseases, 13(12)

Tian S, Wang C, Chang HH. (2018). To select relevant features for longitudinal gene expression data by extending a pathway analysis method. F1000Research, (7)

Pan A, Sarnat SE, Chang HH. (2018). Time-Series Analysis of Air Pollution and Health Accounting for Covariate-Dependent Overdispersion. American journal of epidemiology, 187(12)

Tian S, Wang C, Chang HH. (2018). A longitudinal feature selection method identifies relevant genes to distinguish complicated injury and uncomplicated injury over time. BMC medical informatics and decision making, 18(Suppl 5)

Chen T, Sarnat SE, Grundstein AJ, Winquist A, Chang HH. (2017). Time-series Analysis of Heat Waves and Emergency Department Visits in Atlanta, 1993 to 2012. Environmental health perspectives, 125(5)

Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S, Cohen C, Gran JM, Schanzer D, Cowling BJ, Wu P, Kyncl J, Ang LW, Park M, Redlberger-Fritz M, Yu H, Espenhain L, Krishnan A, Emukule G, van Asten L, Pereira da Silva S, Aungkulanon S, Buchholz U, Widdowson MA, Bresee JS, . (2018). Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet, 391(10127)

Chang HHY, Pannunzio NR, Adachi N, Lieber MR. (2017). Non-homologous DNA end joining and alternative pathways to double-strand break repair. Nature reviews. Molecular cell biology, 18(8)

Sheehan MC, Lam J, Navas-Acien A, Chang HH. (2016). Ambient air pollution epidemiology systematic review and meta-analysis: A review of reporting and methods practice. Environment international, (92-93)

Chang HH, Lieber MR. (2016). Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex. Nucleic acids research, 44(11)

Chang HH, Watanabe G, Gerodimos CA, Ochi T, Blundell TL, Jackson SP, Lieber MR. (2016). Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency. The Journal of biological chemistry, 291(47)

Head JR, Chang H, Li Q, Hoover CM, Wilke T, Clewing C, Carlton EJ, Liang S, Lu D, Zhong B, Remais JV. (2016). Genetic Evidence of Contemporary Dispersal of the Intermediate Snail Host of Schistosoma japonicum: Movement of an NTD Host Is Facilitated by Land Use and Landscape Connectivity. PLoS neglected tropical diseases, 10(12)

Krall JR, Chang HH, Sarnat SE, Peng RD, Waller LA. (2015). Current Methods and Challenges for Epidemiological Studies of the Associations Between Chemical Constituents of Particulate Matter and Health. Current environmental health reports, 2(4)

Chang HH, Watanabe G, Lieber MR. (2015). Unifying the DNA end-processing roles of the artemis nuclease: Ku-dependent artemis resection at blunt DNA ends. The Journal of biological chemistry, 290(40)

Chang HH, Warren JL, Darrow LA, Reich BJ, Waller LA. (2015). Assessment of critical exposure and outcome windows in time-to-event analysis with application to air pollution and preterm birth study. Biostatistics (Oxford, England), 16(3)

Gray SC, Massaro T, Chen I, Edholm CJ, Grotheer R, Zheng Y, Chang HH. (2015). A county-level analysis of persons living with HIV in the southern United States. AIDS Care, 28(2)

Lorenz A, Dhingra R, Chang HH, Bisanzio D, Liu Y, Remais JV. (2014). Inter-model comparison of the landscape determinants of vector-borne disease: implications for epidemiological and entomological risk modeling. PLoS One, 9(7)

Chang HH, Hao H, Sarnat SE. (2014). A Statistical Modeling Framework for Projecting Future Ambient Ozone and its Health Impact due to Climate Change. Atmospheric environment (Oxford, England : 1994), (89)

Dionisio KL, Baxter LK, Chang HH. (2014). An empirical assessment of exposure measurement error and effect attenuation in bipollutant epidemiologic models. Environmental health perspectives, 122(11)

Chang HH, Hu X, Liu Y. (2014). Calibrating MODIS aerosol optical depth for predicting daily PM2.5 concentrations via statistical downscaling. Journal of exposure science & environmental epidemiology, 24(4)

Dhingra R, Jimenez V, Chang HH, Gambhir M, Fu JS, Liu Y, Remais JV. (2013). Spatially-Explicit Simulation Modeling of Ecological Response to Climate Change: Methodological Considerations in Predicting Shifting Population Dynamics of Infectious Disease Vectors. ISPRS international journal of geo-information, 2(3)

Chang HH, Reich BJ, Miranda ML. (2013). A spatial time-to-event approach for estimating associations between air pollution and preterm birth. Journal of the Royal Statistical Society. Series C, Applied statistics, 62(2)

Chang HH, Fuentes M, Frey HC. (2012). Time series analysis of personal exposure to ambient air pollution and mortality using an exposure simulator. Journal of exposure science & environmental epidemiology, 22(5)

Chang HH, Reich BJ, Miranda ML. (2012). Time-to-event analysis of fine particle air pollution and preterm birth: results from North Carolina, 2001-2005. American journal of epidemiology, 175(2)

Chang HH, Peng RD, Dominici F. (2011). Estimating the acute health effects of coarse particulate matter accounting for exposure measurement error. Biostatistics (Oxford, England), 12(4)

Chang HH, Zhou J, Fuentes M. (2010). Impact of climate change on ambient ozone level and mortality in southeastern United States. International journal of environmental research and public health, 7(7)

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