Isaac G Freedman, MD MPH is a Resident Physician and researcher at the Massachusetts General Hospital and Harvard Medical School. His research interests include anesthesiology, perioperative outcomes, healthcare policy and economics, biostatistics, and neuroscience.
He/him/his
Brazil
Turkey
United States
China
McKay TB, Smith M, Mueller A, Li H, Patel PH, Freedman IG, Qu JZ, Akeju O. (2025). Nighttime dexmedetomidine modifies the association between neurofilament light chain and delirium severity after major cardiac surgery: a secondary analysis of the MINDDS trial. GeroScience
McKay TB, Smith M, Mueller A, Li H, Patel PH, Freedman IG, Qu JZ, Akeju O. (2025). Associations between Aβ40, Aβ42, and tau and postoperative delirium in older adults undergoing cardiac surgery. Journal of neurology, 272(6)
Freedman IG, Li J. (2025). Continuous Adductor Canal Block Compared to Epidural Anesthesia for Total Knee Arthroplasty [Response to Letter]. Journal of pain research, (18)
Freedman IG, Boncompte G, Qu JZ, Khawaja ZQ, Turco I, Mueller A, Wiredu K, McKay TB, Westover MB, Pedemonte JC, Akeju O. (2025). Anesthesia-induced electroencephalogram oscillations and perioperative outcomes in older adults undergoing cardiac surgery. Journal of clinical anesthesia, (102)
Boncompte G, Freedman I, Qu J, Turco I, Khawaja ZQ, Cortinez I, Pedemonte JC, Akeju O. (2024). Cognitive function mediates the relationship between age and anaesthesia-induced oscillatory-specific alpha power. Brain communications, 6(1)
Sandhu MRS, Schonwald A, Boyko M, Jafar TD, Freedman IG, Woeste J, Kurup A, Funaro MC, Zlotnik A, Gruenbaum SE, Elsamadicy AA, Reynolds RA, Gruenbaum BF. (2024). The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews
Freedman IG, Mercier MR, Galivanche AR, Sandhu MRS, Hocevar M, Moore HG, Grauer JN, Rubin LE, Li J. (2024). Continuous Adductor Canal Block Compared to Epidural Anesthesia for Total Knee Arthroplasty. Journal of pain research, (17)
Hengartner AC, Havlik J, David WB, Reeves BC, Freedman IG, Sarkozy M, Maloy G, Fernandez T, Craft S, Koo AB, Tuason DA, DiLuna M, Elsamadicy AA. (2023). Association Between Intravenous to Oral Opioid Transition Time and Length of Hospital Stay After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis. International journal of spine surgery, 17(3)
McCafferty C, Gruenbaum BF, Tung R, Li JJ, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu JH, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson EA, Vitkovskiy P, Sampognaro J, Freedman IG, Kundishora A, Depaulis A, David F, Crunelli V, Sanganahalli BG, Herman P, Hyder F, Blumenfeld H. (2023). Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature communications, 14(1)
Freedman IG, Li E, Hui L, Adelman RA, Nwanyanwu K, Wang JC. (2022). The Impact of Image Processing Algorithms on Optical Coherence Tomography Angiography Metrics and Study Conclusions in Diabetic Retinopathy. Translational vision science & technology, 11(9)
Mehta SK, Mir T, Freedman IG, Sheth AH, Sarrafpour S, Liu J, Teng CC. (2022). Emergency Department Presentations of Acute Primary Angle Closure in the United States from 2008 to 2017. Clinical ophthalmology (Auckland, N.Z.), (16)
Koo AB, Elsamadicy AA, Sarkozy M, Pathak N, David WB, Freedman IG, Reeves BC, Sciubba DM, Laurans M, Kolb L. (2022). Geographic variations in health care resource utilization following elective ACDF for cervical spondylotic myelopathy: A national trend analysis. North American Spine Society journal, (9)
Elsamadicy AA, Sandhu MRS, Reeves BC, Freedman IG, Koo AB, Jayaraj C, Hengartner AC, Havlik J, Hersh AM, Pennington Z, Lo SL, Shin JH, Mendel E, Sciubba DM. (2022). Association of inpatient opioid consumption on postoperative outcomes after open posterior spinal fusion for adult spine deformity. Spine deformity
Elsamadicy AA, Sandhu MRS, Freedman IG, Koo AB, Reeves BC, Yu J, Hengartner A, Havlik J, Hong CS, Rutherford HJV, Kim JA, Gerrard J, Gilmore EJ, Omay SB. (2022). Impact of Frailty on Morbidity and Mortality in Adult Patients Undergoing Surgical Evacuation of Acute Traumatic Subdural Hematoma. World neurosurgery
Elsamadicy AA, Freedman I, Koo AB, David WB, Reeves BC, Hengartner A, Pennington Z, Laurans M, Kolb L, Shin JH, Sciubba D. (2021). Impact of Racial Disparities on All-Cause Mortality in Patients With Tumors of the Spinal Cord or Spinal Meninges: A Propensity-Score Analysis. Global spine journal
Elsamadicy AA, Sandhu MR, Freedman IG, Koo AB, Hengartner AC, Reeves BC, Havlik J, Sarkozy M, Hong CS, Kundishora AJ, Tuason DA, DiLuna M. (2021). Racial Disparities in Healthcare Resource Utilization After Pediatric Cervical and/or Thoracic Spinal Injuries. World neurosurgery
Elsamadicy AA, Freedman IG, Koo AB, David W, Hengartner AC, Havlik J, Reeves BC, Hersh A, Pennington Z, Kolb L, Laurans M, Shin JH, Sciubba DM. (2021). Patient- and hospital-related risk factors for non-routine discharge after lumbar decompression and fusion for spondylolisthesis. Clinical neurology and neurosurgery, (209)
Elsamadicy AA, Koo AB, Reeves BC, Freedman IG, Pennington Z, David WB, Ehresman J, Hengartner A, Laurans M, Kolb L, Shin JH, Sciubba DM. (2021). Cost and Health Care Resource Utilization Differences After Spine Surgery for Bony Spine versus Primary Intradural Spine Tumors. World neurosurgery, (151)
Elsamadicy AA, Freedman IG, Koo AB, David WB, Reeves BC, Havlik J, Pennington Z, Kolb L, Shin JH, Sciubba DM. (2021). Modified-frailty index does not independently predict complications, hospital length of stay or 30-day readmission rates following posterior lumbar decompression and fusion for spondylolisthesis. The spine journal : official journal of the North American Spine Society
Elsamadicy AA, Koo AB, David WB, Freedman IG, Kundishora AJ, Hong CS, Sarkozy M, Sciubba DM, Kahle KT, DiLuna M. (2021). Impact of race on outcomes and healthcare utilization following spinal fusion for adolescent idiopathic scoliosis. Clinical neurology and neurosurgery, (206)
Elsamadicy AA, Freedman IG, Koo AB, David WB, Havlik J, Kundishora AJ, Sciubba DM, Kahle KT, DiLuna M. (2021). The Effects of Pulmonary Risk Factors on Hospital Resource Use After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Correction. World neurosurgery, (149)
Elsamadicy AA, Koo AB, David WB, Reeves BC, Freedman IG, Pennington Z, Ehresman J, Kolb L, Laurans M, Shin JH, Sciubba DM. (2021). Race Is an Independent Predictor for Nonroutine Discharges After Spine Surgery for Spinal Intradural/Cord Tumors. World neurosurgery, (151)
Elsamadicy AA, Koo AB, David WB, Sarkozy M, Freedman IG, Reeves BC, Laurans M, Kolb L, Sciubba DM. (2020). Portending Influence of Racial Disparities on Extended Length of Stay after Elective Anterior Cervical Discectomy and Interbody Fusion for Cervical Spondylotic Myelopathy. World neurosurgery, (142)
Elsamadicy AA, Freedman IG, Koo AB, David WB, Havlik J, Kundishora AJ, Hong CS, Sciubba DM, Kahle KT, DiLuna M. (2021). Impact of Preoperative Anemia on Outcomes After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis. World neurosurgery, (146)
Ma AK, Freedman I, Lee JH, Miyagishima D, Ahmed O, Yeung J. (2020). Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma. Cureus, 12(2)
Koo AB, Yeung JT, Freedman IG, Lee JH, Ahmed OM, Ma AK, Miyagishima DF, DiLuna M, Kahle K. (2020). Clinical and economic burden of neurofibromatosis type 2 in the United States. Clinical neurology and neurosurgery, (197)
Elsamadicy AA, Freedman IG, Koo AB, David WB, Lee M, Kundishora AJ, Kuzmik GA, Gorrepati R, Hong CS, Kolb L, Laurans M, Abbed K. (2020). Influence of gender on discharge disposition after spinal fusion for adult spine deformity correction. Clinical neurology and neurosurgery, (194)
Elsamadicy AA, Koo AB, Lee M, David WB, Kundishora AJ, Freedman IG, Zogg CK, Hong CS, DeSpenza T, Sarkozy M, Kahle KT, DiLuna M. (2020). Risk Factors Portending Extended Length of Stay After Suboccipital Decompression for Adult Chiari I Malformation. World neurosurgery, (138)
Elsamadicy AA, Freedman IG, Koo AB, Reeves BC, Havlik J, David WB, Hong CS, Kolb L, Laurans M, Matouk CC, DiLuna M. (2020). Characteristics of Reported Industry Payments to Neurosurgeons: A 5-Year Open Payments Database Study. World neurosurgery, (145)
Freedman I, Koo A, Yeagle E, Diluna M, Kolb L, Yeung J. (2020). Does neurofibromatosis 1 status impact outcomes for pediatric/young adults undergoing spinal fusion?. Surgical neurology international, (11)
Yue Z, Freedman IG, Vincent P, Andrews JP, Micek C, Aksen M, Martin R, Zuckerman D, Perrenoud Q, Neske GT, Sieu LA, Bo X, Cardin JA, Blumenfeld H. (2020). Up and Down States of Cortical Neurons in Focal Limbic Seizures. Cerebral cortex (New York, N.Y. : 1991), 30(5)
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