Natalie Dean – MIDAS

Natalie Dean

Assistant Professor

Education

Affiliations

Department of Biostatistics, College of Public Health and Health Professions, University of Florida
Center for Inference & Dynamics of Infectious Disease, Fred Hutchinson Cancer Research Center

Projects

DESIGN AND ANALYSIS OF VACCINE TRIALS FOR EMERGING INFECTIOUS DISEASE THREATS

National Institutes of Health, National Institute of Allergy and Infectious Diseases
People: Ira Longini, Natalie Dean
2018 – 2023

METHODS FOR EVALUATING VACCINE EFFICACY

National Institutes of Health, National Institute of Allergy and Infectious Diseases
People: Ira Longini, Natalie Dean, Yang Yang, M Halloran
2015 – 2020

CENTER FOR STATISTICS AND QUANTITATIVE INFECTIOUS DISEASES

National Institutes of Health, National Institute of General Medical Sciences
People: Natalie Dean, Katia Koelle, Molly Gallagher, John Drake, Laura Matrajt, Diana Rojas Alvarez, Eben Kenah, Aaron King, Marco Ajelli, Ana Pastore y Piontti, Yang Yang, M Halloran, Pejman Rohani
2014 – 2020

Papers

Dean N. (2021). Hospital admissions due to COVID-19 in Scotland after one dose of vaccine. Lancet

Giovanetti M, Cella E, Benedetti F, Rife Magalis B, Fonseca V, Fabris S, Campisi G, Ciccozzi A, Angeletti S, Borsetti A, Tambone V, Sagnelli C, Pascarella S, Riva A, Ceccarelli G, Marcello A, Azarian T, Wilkinson E, de Oliveira T, Alcantara LCJ, Cauda R, Caruso A, Dean NE, Browne C, Lourenço J, Salemi M, Zella D, Ciccozzi M. (2021). SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy. Communications biology, 4(1)

Li F, Li YY, Liu MJ, Fang LQ, Dean NE, Wong GWK, Yang XB, Longini I, Halloran ME, Wang HJ, Liu PL, Pang YH, Yan YQ, Liu S, Xia W, Lu XX, Liu Q, Yang Y, Xu SQ. (2021). Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity in Wuhan: a retrospective observational study. The Lancet. Infectious diseases

Hitchings MDT, Dean NE, Garcia-Carreras B, Hladish TJ, Huang AT, Yang B, Cummings DAT. (2021). The Usefulness Of SARS-CoV-2 Test-Positive Proportion As A Surveillance Tool. American journal of epidemiology

Dean N. (2021). Statistical successes and failures during the COVID-19 pandemic: Comments on Ellenberg and Morris. Statistics in medicine, 40(11)

Madewell ZJ, Pastore Y Piontti A, Zhang Q, Burton N, Yang Y, Longini IM, Halloran ME, Vespignani A, Dean NE. (2021). Using simulated infectious disease outbreaks to inform site selection and sample size for individually randomized vaccine trials during an ongoing epidemic. Clinical trials (London, England)

Madewell ZJ, Yang Y, Longini IM Jr., Halloran ME, Dean NE. (2020). Household transmission of SARS-CoV-2: a systematic review and meta-analysis of secondary attack rate. medRxiv : the preprint server for health sciences

Madewell ZJ, Yang Y, Longini IM Jr., Halloran ME, Dean NE. (2020). Household Transmission of SARS-CoV-2: A Systematic Review and Meta-analysis. JAMA network open, 3(12)

Lipsitch M, Dean NE. (2020). Understanding COVID-19 vaccine efficacy. Science (New York, N.Y.)

Aleta A, Martin-Corral D, Pastore Y Piontti A, Ajelli M, Litvinova M, Chinazzi M, Dean NE, Halloran ME, Longini IM, Merler S, Pentland A, Vespignani A, Moro E, Moreno Y. (2020). Modeling the impact of social distancing, testing, contact tracing and household quarantine on second-wave scenarios of the COVID-19 epidemic. medRxiv : the preprint server for health sciences

Jing QL, Liu MJ, Zhang ZB, Fang LQ, Yuan J, Zhang AR, Dean NE, Luo L, Ma MM, Longini I, Kenah E, Lu Y, Ma Y, Jalali N, Yang ZC, Yang Y. (2020). Household secondary attack rate of COVID-19 and associated determinants in Guangzhou, China: a retrospective cohort study. The Lancet. Infectious diseases

Dean NE, Halloran ME, Longini IM Jr.. (2020). Temporal Confounding in the Test Negative Design. American journal of epidemiology

Kimmel SE, Califf RM, Dean NE, Goodman SN, Ogburn EL. (2020). COVID-19 Clinical Trials: A Teachable Moment for Improving Our Research Infrastructure and Relevance. Annals of internal medicine

Cardel MI, Dean N, Montoya-Williams D. (2020). Preventing a Secondary Epidemic of Lost Early Career Scientists: Effects of COVID-19 Pandemic on Women with Children. Annals of the American Thoracic Society

Jing QL, Liu MJ, Yuan J, Zhang ZB, Zhang AR, Dean NE, Luo L, Ma M, Longini I, Kenah E, Lu Y, Ma Y, Jalali N, Fang LQ, Yang ZC, Yang Y. (2020). Household Secondary Attack Rate of COVID-19 and Associated Determinants. medRxiv : the preprint server for health sciences

Dean NE, Pastore Y Piontti A, Madewell ZJ, Cummings DAT, Hitchings MDT, Joshi K, Kahn R, Vespignani A, Halloran ME, Longini IM Jr.. (2020). Ensemble forecast modeling for the design of COVID-19 vaccine efficacy trials. Vaccine

Ogburn EL, Bierer BE, Brookmeyer R, Choirat C, Dean NE, De Gruttola V, Ellenberg SS, Halloran ME, Hanley DF Jr., Lee JK, Wang R, Scharfstein DO. (2020). Aggregating data from COVID-19 trials. Science (New York, N.Y.), 368(6496)

Jordan MR, Hamunime N, Bikinesi L, Sawadogo S, Agolory S, Shiningavamwe AN, Negussie T, Fisher-Walker CL, Raizes EG, Mutenda N, Hunter CJ, Dean N, Steegen K, Kana V, Carmona S, Yang C, Tang AM, Parkin N, Hong SY. (2020). High levels of HIV drug resistance among adults failing second-line antiretroviral therapy in Namibia. Medicine, 99(37)

Manrique-Saide P, Dean NE, Halloran ME, Longini IM, Collins MH, Waller LA, Gomez-Dantes H, Lenhart A, Hladish TJ, Che-Mendoza A, Kirstein OD, Romer Y, Correa-Morales F, Palacio-Vargas J, Mendez-Vales R, Pérez PG, Pavia-Ruz N, Ayora-Talavera G, Vazquez-Prokopec GM. (2020). The TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor residual spraying to reduce Aedes-borne viral illnesses in Merida, Mexico. Trials, 21(1)

Davis JT, Chinazzi M, Perra N, Mu K, Piontti APY, Ajelli M, Dean NE, Gioannini C, Litvinova M, Merler S, Rossi L, Sun K, Xiong X, Halloran ME, Longini IM Jr., Viboud C, Vespignani A. (2020). Estimating the establishment of local transmission and the cryptic phase of the COVID-19 pandemic in the USA. medRxiv : the preprint server for health sciences

Aleta A, Martín-Corral D, Pastore Y Piontti A, Ajelli M, Litvinova M, Chinazzi M, Dean NE, Halloran ME, Longini IM Jr., Merler S, Pentland A, Vespignani A, Moro E, Moreno Y. (2020). Modelling the impact of testing, contact tracing and household quarantine on second waves of COVID-19. Nature human behaviour

Dean NE, Gsell PS, Brookmeyer R, Crawford FW, Donnelly CA, Ellenberg SS, Fleming TR, Halloran ME, Horby P, Jaki T, Krause PR, Longini IM, Mulangu S, Muyembe-Tamfum JJ, Nason MC, Smith PG, Wang R, Henao-Restrepo AM, De Gruttola V. (2020). Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks. The New England journal of medicine, 382(14)

Yang Yang, Lu Qingbin, Liu Mingjin, Wang Yixing, Zhang Anran, Jalali Neda, Dean Natalie, Longini Ira, Halloran M. Elizabeth, Xu Bo, Zhang Xiaoai, Wang Liping, Liu Wei, Fang Liqun. (2019). Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China. Cold Spring Harbor Laboratory Press

Dean NE. (2019). RE: "MEASUREMENT OF VACCINE DIRECT EFFECTS UNDER THE TEST-NEGATIVE DESIGN". American journal of epidemiology, 188(4)

Ding AA, Wu SS, Dean NE, Zahigian RS. (2019). Two-stage adaptive enrichment design for testing an active factor. Journal of biopharmaceutical statistics, 30(1)

Bellan SE, Eggo RM, Gsell PS, Kucharski AJ, Dean NE, Donohue R, Zook M, Edmunds WJ, Odhiambo F, Longini IM Jr., Brisson M, Mahon BE, Henao-Restrepo AM. (2019). An online decision tree for vaccine efficacy trial design during infectious disease epidemics: The InterVax-Tool. Vaccine, 37(31)

Hunt GM, Ledwaba J, Kalimashe M, Salimo A, Cibane S, Singh B, Puren A, Dean NE, Morris L, Jordan MR. Provincial and national prevalence estimates of transmitted HIV-1 drug resistance in South Africa measured using two WHO-recommended methods. Antiviral therapy, 24(3)

Dean NE, Gsell PS, Brookmeyer R, De Gruttola V, Donnelly CA, Halloran ME, Jasseh M, Nason M, Riveros X, Watson CH, Henao-Restrepo AM, Longini IM. (2019). Design of vaccine efficacy trials during public health emergencies. Science translational medicine, 11(499)

Dean NE, Halloran ME, Longini IM. (2018). Design of vaccine trials during outbreaks with and without a delayed vaccination comparator. The annals of applied statistics, 12(1)

Ma MJ, Zhao T, Chen SH, Xia X, Yang XX, Wang GL, Fang LQ, Ma GY, Wu MN, Qian YH, Dean NE, Yang Y, Lu B, Cao WC. (2018). Avian Influenza A Virus Infection among Workers at Live Poultry Markets, China, 2013-2016. Emerging infectious diseases, 24(7)

Sun K, Zhang Q, Pastore-Piontti A, Chinazzi M, Mistry D, Dean NE, Rojas DP, Merler S, Poletti P, Rossi L, Halloran ME, Longini IM Jr., Vespignani A. (2018). Quantifying the risk of local Zika virus transmission in the contiguous US during the 2015-2016 ZIKV epidemic. BMC medicine, 16(1)

Zhang Q, Sun K, Chinazzi M, Pastore Y Piontti A, Dean NE, Rojas DP, Merler S, Mistry D, Poletti P, Rossi L, Bray M, Halloran ME, Longini IM Jr., Vespignani A. (2017). Spread of Zika virus in the Americas. Proceedings of the National Academy of Sciences of the United States of America, 114(22)

Merler S, Ajelli M, Fumanelli L, Parlamento S, Pastore Y Piontti A, Dean NE, Putoto G, Carraro D, Longini IM Jr., Halloran ME, Vespignani A. (2016). Containing Ebola at the Source with Ring Vaccination. PLoS neglected tropical diseases, 10(11)

Henao-Restrepo AM, Camacho A, Longini IM, Watson CH, Edmunds WJ, Egger M, Carroll MW, Dean NE, Diatta I, Doumbia M, Draguez B, Duraffour S, Enwere G, Grais R, Gunther S, Gsell PS, Hossmann S, Watle SV, Kondé MK, Kéïta S, Kone S, Kuisma E, Levine MM, Mandal S, Mauget T, Norheim G, Riveros X, Soumah A, Trelle S, Vicari AS, Røttingen JA, Kieny MP. (2017). Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!). Lancet, 389(10068)

Rojas DP, Dean NE, Yang Y, Kenah E, Quintero J, Tomasi S, Ramirez EL, Kelly Y, Castro C, Carrasquilla G, Halloran ME, Longini IM. (2016). The epidemiology and transmissibility of Zika virus in Girardot and San Andres island, Colombia, September 2015 to January 2016. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 21(28)

Ajelli M, Merler S, Fumanelli L, Pastore Y Piontti A, Dean NE, Longini IM Jr., Halloran ME, Vespignani A. (2016). Spatiotemporal dynamics of the Ebola epidemic in Guinea and implications for vaccination and disease elimination: a computational modeling analysis. BMC medicine, 14(1)

Dean NE, Halloran ME, Yang Y, Longini IM. (2016). Transmissibility and Pathogenicity of Ebola Virus: A Systematic Review and Meta-analysis of Household Secondary Attack Rate and Asymptomatic Infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 62(10)

Fang LQ, Yang Y, Jiang JF, Yao HW, Kargbo D, Li XL, Jiang BG, Kargbo B, Tong YG, Wang YW, Liu K, Kamara A, Dafae F, Kanu A, Jiang RR, Sun Y, Sun RX, Chen WJ, Ma MJ, Dean NE, Thomas H, Longini IM Jr., Halloran ME, Cao WC. (2016). Transmission dynamics of Ebola virus disease and intervention effectiveness in Sierra Leone. Proceedings of the National Academy of Sciences of the United States of America, 113(16)

Longini IM, Egger M, Dean NE, Edmunds WJ, Henao-Restrepo AM, . (2015). Ebola vaccination - Authors' reply. Lancet, 386(10012)

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