Nicholas DeFelice, PhD, is Assistant Professor in the Department of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai and a member of the Mount Sinai Institute for Exposomic Research. Dr. DeFelice studies the environmental determinants of infectious disease transmission. He develops mathematical models that quantify the burden of disease attributable to poor infrastructure and other environmental exposures, along with systems to forecast infectious disease outbreaks. His current research focuses on forecasting West Nile virus outbreaks. More broadly, his research is addressing how climate change influences human health and the environmental solutions that can promote positive health outcomes. Dr. DeFelice holds a PhD in Environmental Science and Engineering at the Gillings School of Global Public Health at the University of North Carolina at Chapel Hill where he also completed his Master of Science in Environmental Engineering. Prior to joining Mount Sinai, his postdoctoral training was completed at Columbia University with a focus on climate and health.
He/him/his
National Institutes of Health, National Institute of General Medical Sciences
People: James (Mac) Hyman, Nicholas DeFelice, Teresa Yamana, Jeffrey Shaman
2014 – 2020 Continue Reading Development and Dissemination of Operational Real-Time Respiratory Virus Forecast
Gennings C, Midya V, Renzetti S, DeFelice N. (2025). Weighted quantile sum (WQS) mixed-effects model. MethodsX, (15)
Harp RD, Holcomb KM, Retkute R, Prusokiene A, Prusokas A, Ertem Z, Ajelli M, Kummer AG, Litvinova M, Merler S, Piontti APY, Poletti P, Vespignani A, Wilke ABB, Zardini A, Smith KH, Armstrong P, DeFelice N, Keyel A, Shepard J, Smith R, Tyre A, Humphreys J, Cohnstaedt LW, Hosseini S, Scoglio C, Gorris ME, Barnard M, Moser SK, Spencer JA, McCarter MSJ, Lee C, Nolan MS, Barker CM, Staples JE, Nett RJ, Johansson MA. (2025). Evaluation of the 2022 West Nile virus forecasting challenge, USA. Parasites & vectors, 18(1)
McCuskee S, Kowalski R, Mei C, Zebrowski A, Patel A, Zajac L, Zikry H, Ayyash A, DeFelice N. (2026). Concurrent Viral Transmission and Wildfire Smoke Events Following COVID-19 Pandemic School Closures in New York City: Associations of a Large Natural Experiment With Acute Care for Pediatric Asthma, 2018-2023. Journal of the American College of Emergency Physicians open, 7(1)
Cusick M, Rowland ST, DeFelice N. (2023). Impact of air pollution on running performance. Scientific reports, 13(1)
Thanik E, Harada K, Garland E, Bixby M, Bhatia J, Lopez R, Galvez S, Dayanov E, Vemuri K, Bush D, DeFelice NB. (2023). Impact of COVID-19 on pediatric asthma-related healthcare utilization in New York City: a community-based study. BMC pediatrics, 23(1)
Holcomb KM, Mathis S, Staples JE, Fischer M, Barker CM, Beard CB, Nett RJ, Keyel AC, Marcantonio M, Childs ML, Gorris ME, Rochlin I, Hamins-Puértolas M, Ray EL, Uelmen JA, DeFelice N, Freedman AS, Hollingsworth BD, Das P, Osthus D, Humphreys JM, Nova N, Mordecai EA, Cohnstaedt LW, Kirk D, Kramer LD, Harris MJ, Kain MP, Reed EMX, Johansson MA. (2023). Evaluation of an open forecasting challenge to assess skill of West Nile virus neuroinvasive disease prediction. Parasites & vectors, 16(1)
Ward MJ, Sorek-Hamer M, Henke JA, Little E, Patel A, Shaman J, Vemuri K, DeFelice NB. (2023). A Spatially Resolved and Environmentally Informed Forecast Model of West Nile Virus in Coachella Valley, California. GeoHealth, 7(12)
Dubowski K, Braganza GT, Bozack A, Colicino E, DeFelice N, McGuinn L, Maru D, Lee AG. (2023). COVID-19 subphenotypes at hospital admission are associated with mortality: a cross-sectional study. Annals of medicine, 55(1)
Cousins K, DeFelice N, Jeong S, Feng J, Lee ASE, Rotella K, Sanchez D, Jaber F, Agarwal S, Ho HE, Cunningham-Rundles C. (2022). SARS-COV-2 infections in inborn errors of immunity: A single center study. Frontiers in immunology, (13)
McGuinn LA, Rivera NR, Osorio-Valencia E, Schnaas L, Hernandez-Chavez C, DeFelice NB, Harari H, Klein DN, Wright RJ, Téllez-Rojo MM, Wright RO, Rosa MJ, Tamayo-Ortiz M. (2023). Changes in depressive and anxiety symptoms during COVID-19 in children from the PROGRESS cohort. Pediatric research, 94(1)
Ward MJ, Sorek-Hamer M, Vemuri KK, DeFelice NB. Statistical Tools for West Nile Virus Disease Analysis. Methods in molecular biology (Clifton, N.J.), (2585)
Keyel AC, Gorris ME, Rochlin I, Uelmen JA, Chaves LF, Hamer GL, Moise IK, Shocket M, Kilpatrick AM, DeFelice NB, Davis JK, Little E, Irwin P, Tyre AJ, Helm Smith K, Fredregill CL, Elison Timm O, Holcomb KM, Wimberly MC, Ward MJ, Barker CM, Rhodes CG, Smith RL. (2021). A proposed framework for the development and qualitative evaluation of West Nile virus models and their application to local public health decision-making. PLoS neglected tropical diseases, 15(9)
Fiore VG, DeFelice N, Glicksberg BS, Perl O, Shuster A, Kulkarni K, O'Brien M, Pisauro MA, Chung D, Gu X. (2021). Containment of COVID-19: Simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation. PloS one, 16(3)
Carrión D, Colicino E, Pedretti NF, Arfer KB, Rush J, DeFelice N, Just AC. (2021). Neighborhood-level disparities and subway utilization during the COVID-19 pandemic in New York City. Nature communications, 12(1)
Carrión D, Colicino E, Pedretti NF, Arfer KB, Rush J, DeFelice N, Just AC. (2020). Assessing capacity to social distance and neighborhood-level health disparities during the COVID-19 pandemic. medRxiv : the preprint server for health sciences
Fiore VG, DeFelice N, Glicksberg BS, Perl O, Shuster A, Kulkarni K, O'Brien M, Pisauro MA, Chung D, Gu X. (2020). Containment of future waves of COVID-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation. medRxiv : the preprint server for health sciences
DeFelice NB, Birger R, DeFelice N, Gagner A, Campbell SR, Romano C, Santoriello M, Henke J, Wittie J, Cole B, Kaiser C, Shaman J. (2019). Modeling and Surveillance of Reporting Delays of Mosquitoes and Humans Infected With West Nile Virus and Associations With Accuracy of West Nile Virus Forecasts. JAMA network open, 2(4)
DeFelice NB, Schneider ZD, Little E, Barker C, Caillouet KA, Campbell SR, Damian D, Irwin P, Jones HMP, Townsend J, Shaman J. (2018). Use of temperature to improve West Nile virus forecasts. PLoS computational biology, 14(3)
DeFelice NB, Little E, Campbell SR, Shaman J. (2017). Ensemble forecast of human West Nile virus cases and mosquito infection rates. Nature communications, (8)
DeFelice NB, Johnston JE, Gibson JM. (2016). Reducing Emergency Department Visits for Acute Gastrointestinal Illnesses in North Carolina (USA) by Extending Community Water Service. Environmental health perspectives, 124(10)
DeFelice NB, Johnston JE, Gibson JM. (2015). Acute Gastrointestinal Illness Risks in North Carolina Community Water Systems: A Methodological Comparison. Environmental science & technology, 49(16)
MacDonald Gibson J, Thomsen J, Launay F, Harder E, DeFelice N. (2013). Deaths and medical visits attributable to environmental pollution in the United Arab Emirates. PloS one, 8(3)
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