Ted Cohen

Associate Professor





National Institutes of Health, National Institute of General Medical Sciences
People: Laura White, Ted Cohen, William Hanage, Rene Niehus, Ben Cowling, Tyler Brown, Joseph Wu, Mauricio Santillana Guzman, Joseph Lewnard, Aimee Taylor, Pablo Martinez de Salazar, Lerato Magosi, Edward Goldstein, Christine Tedijanto, Tigist Menkir, Sze Man Leung, Hsiao-Han Chang, Caroline Buckee, Pamela Martinez, Marc Lipsitch
2009 – 2020

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Cudahy PGT, Andrews JR, Bilinski A, Dowdy DW, Mathema B, Menzies NA, Salomon JA, Shrestha S, Cohen T. (2019). Spatially targeted screening to reduce tuberculosis transmission in high-incidence settings. The Lancet. Infectious diseases, 19(3)

Zimmer C, Leuba SI, Yaesoubi R, Cohen T. (2018). Use of daily Internet search query data improves real-time projections of influenza epidemics. Journal of the Royal Society, Interface, 15(147)

Warren JL, Grandjean L, Moore DAJ, Lithgow A, Coronel J, Sheen P, Zelner JL, Andrews JR, Cohen T. (2018). Investigating spillover of multidrug-resistant tuberculosis from a prison: a spatial and molecular epidemiological analysis. BMC medicine, 16(1)

Marx FM, Yaesoubi R, Menzies NA, Salomon JA, Bilinski A, Beyers N, Cohen T. (2018). Tuberculosis control interventions targeted to previously treated people in a high-incidence setting: a modelling study. The Lancet. Global health, 6(4)

Yaesoubi R, Trotter C, Colijn C, Yaesoubi M, Colombini A, Resch S, Kristiansen PA, LaForce FM, Cohen T. (2018). The cost-effectiveness of alternative vaccination strategies for polyvalent meningococcal vaccines in Burkina Faso: A transmission dynamic modeling study. PLoS medicine, 15(1)

Zelner J, Murray M, Becerra M, Galea J, Lecca L, Calderon R, Yataco R, Zhang Z, Cohen T. (2018). Protective effects of household-based TB interventions are robust to neighbourhood-level variation in exposure risk in Lima, Peru: a model-based analysis. International journal of epidemiology, 47(1)

Yang C, Lu L, Warren JL, Wu J, Jiang Q, Zuo T, Gan M, Liu M, Liu Q, DeRiemer K, Hong J, Shen X, Colijn C, Guo X, Gao Q, Cohen T. (2018). Internal migration and transmission dynamics of tuberculosis in Shanghai, China: an epidemiological, spatial, genomic analysis. The Lancet. Infectious diseases, 18(7)

Abel Zur Wiesch P, Clarelli F, Cohen T. (2017). Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies. PLoS computational biology, 13(1)

Cohen T. (2017). TM Departments Should Operate like a Business: Response to Maddock. Biomedical instrumentation & technology, 51(5)

Kunkel A, Furin J, Cohen T. (2017). Population implications of the use of bedaquiline in people with extensively drug-resistant tuberculosis: are fears of resistance justified?. The Lancet. Infectious diseases, 17(12)

Nathavitharana RR, Shi CX, Chindelevitch L, Calderon R, Zhang Z, Galea JT, Contreras C, Yataco R, Lecca L, Becerra MC, Murray MB, Cohen T. (2017). Polyclonal Pulmonary Tuberculosis Infections and Risk for Multidrug Resistance, Lima, Peru. Emerging infectious diseases, 23(11)

Cohen T. (2017). HTM Departments Should Operate like a Business. Biomedical instrumentation & technology, 51(4)

Kunkel A, Lewnard JA, Pitzer VE, Cohen T. (2017). Antimicrobial Resistance Risks of Cholera Prophylaxis for United Nations Peacekeepers. Antimicrobial agents and chemotherapy, 61(8)

Zimmer C, Yaesoubi R, Cohen T. (2017). A Likelihood Approach for Real-Time Calibration of Stochastic Compartmental Epidemic Models. PLoS computational biology, 13(1)

Cohen T, Chindelevitch L, Misra R, Kempner ME, Galea J, Moodley P, Wilson D. (2016). Reply to Chen et al. The Journal of infectious diseases, 214(8)

Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Manjourides J, Grenfell BT, Cohen T. (2016). Identifying Hotspots of Multidrug-Resistant Tuberculosis Transmission Using Spatial and Molecular Genetic Data. The Journal of infectious diseases, 213(2)

Kunkel A, Abel Zur Wiesch P, Nathavitharana RR, Marx FM, Jenkins HE, Cohen T. (2016). Smear positivity in paediatric and adult tuberculosis: systematic review and meta-analysis. BMC infectious diseases

Kunkel A, Crawford FW, Shepherd J, Cohen T. (2016). Benefits of continuous isoniazid preventive therapy may outweigh resistance risks in a declining tuberculosis/HIV coepidemic. AIDS (London, England), 30(17)

Yaesoubi R, Cohen T. (2016). Identifying cost-effective dynamic policies to control epidemics. Statistics in medicine, 35(28)

Heidebrecht CL, Podewils LJ, Pym A, Mthiyane T, Cohen T. (2016). Assessing Local Risk of Rifampicin-Resistant Tuberculosis in KwaZulu-Natal, South Africa Using Lot Quality Assurance Sampling. PLoS One, 11(4)

Cohen T, Chindelevitch L, Misra R, Kempner ME, Galea J, Moodley P, Wilson D. (2016). Within-Host Heterogeneity of Mycobacterium tuberculosis Infection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study. The Journal of infectious diseases, 213(11)

Colijn C, Cohen T. (2016). Whole-genome sequencing of Mycobacterium tuberculosis for rapid diagnostics and beyond. The Lancet. Respiratory medicine, 4(1)

Kunkel A, Cobelens FG, Cohen T. (2016). Tradeoffs in Introduction Policies for the Anti-Tuberculosis Drug Bedaquiline: A Model-Based Analysis. PLoS medicine, 13(10)

Van Rie A, Cohen T. (2016). The contributions of Steve Lawn to the science, advocacy and policy of HIV-associated TB. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 20(12)

Marx FM, Floyd S, Ayles H, Godfrey-Faussett P, Beyers N, Cohen T. (2016). High burden of prevalent tuberculosis among previously treated people in Southern Africa suggests potential for targeted control interventions. The European respiratory journal, 48(4)

Salvatore PP, Becerra MC, Abel zur Wiesch P, Hinkley T, Kaur D, Sloutsky A, Cohen T. (2016). Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study. The Journal of infectious diseases, 213(1)

Chindelevitch L, Colijn C, Moodley P, Wilson D, Cohen T. (2016). ClassTR: Classifying Within-Host Heterogeneity Based on Tandem Repeats with Application to Mycobacterium tuberculosis Infections. PLoS computational biology, 12(2)

Colijn C, Cohen T. (2015). How competition governs whether moderate or aggressive treatment minimizes antibiotic resistance. Elife

Knight GM, Colijn C, Shrestha S, Fofana M, Cobelens F, White RG, Dowdy DW, Cohen T. (2015). The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Abel Zur Wiesch P, Abel S, Gkotzis S, Ocampo P, Engelstädter J, Hinkley T, Magnus C, Waldor MK, Udekwu K, Cohen T. (2015). Classic reaction kinetics can explain complex patterns of antibiotic action. Science translational medicine, 7(287)

Chindelevitch L, Menzies NA, Pretorius C, Stover J, Salomon JA, Cohen T. (2015). Evaluating the potential impact of enhancing HIV treatment and tuberculosis control programmes on the burden of tuberculosis. Journal of the Royal Society, Interface, 12(106)

Kunkel A, Colijn C, Lipsitch M, Cohen T. (2015). How could preventive therapy affect the prevalence of drug resistance? Causes and consequences. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 370(1670)

Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Grenfell BT, Cohen T. (2014). Age-specific risks of tuberculosis infection from household and community exposures and opportunities for interventions in a high-burden setting. American journal of epidemiology, 180(8)

Jenkins HE, Pagano M, Yuen CM, Becerra MC, Cohen T. (2014). The burden of tuberculosis disease in children--Authors' reply. Lancet (London, England), 384(9951)

Cohen T, Jenkins HE, Lu C, McLaughlin M, Floyd K, Zignol M. (2014). On the spread and control of MDR-TB epidemics: an examination of trends in anti-tuberculosis drug resistance surveillance data. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 17(4-6)

Jenkins HE, Tolman AW, Yuen CM, Parr JB, Keshavjee S, Pérez-Vélez CM, Pagano M, Becerra MC, Cohen T. (2014). Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimates. Lancet (London, England), 383(9928)

Cohen T. (2014). The Basics of CMMS. Biomedical instrumentation & technology, 48(2)

Jenkins HE, Crudu V, Soltan V, Ciobanu A, Domente L, Cohen T. (2014). High risk and rapid appearance of multidrug resistance during tuberculosis treatment in Moldova. The European respiratory journal, 43(4)

Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Grenfell BT, Cohen T. (2014). Bacillus Calmette-Guérin and isoniazid preventive therapy protect contacts of patients with tuberculosis. American journal of respiratory and critical care medicine, 189(7)

Yaesoubi R, Cohen T. (2013). Identifying dynamic tuberculosis case-finding policies for HIV/TB coepidemics. Proceedings of the National Academy of Sciences of the United States of America, 110(23)

Mitnick CD, Keravec J, Cohen T. (2013). Planning for the invisible: projecting resources needed to identify and treat all patients with MDR-TB. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 17(4)

Jenkins HE, Plesca V, Ciobanu A, Crudu V, Galusca I, Soltan V, Serbulenco A, Zignol M, Dadu A, Dara M, Cohen T. (2013). Assessing spatial heterogeneity of multidrug-resistant tuberculosis in a high-burden country. The European respiratory journal, 42(5)

Sergeev R, Colijn C, Murray M, Cohen T. (2012). Modeling the dynamic relationship between HIV and the risk of drug-resistant tuberculosis. Science translational medicine, 4(135)

Lin HH, Shin SS, Contreras C, Asencios L, Paciorek CJ, Cohen T. (2012). Use of spatial information to predict multidrug resistance in tuberculosis patients, Peru. Emerging infectious diseases, 18(5)

Lin HH, Dowdy D, Dye C, Murray M, Cohen T. (2012). The impact of new tuberculosis diagnostics on transmission: why context matters. Bulletin of the World Health Organization, 90(10)

Hedt BL, van Leth F, Zignol M, Cobelens F, van Gemert W, Nhung NV, Lyepshina S, Egwaga S, Cohen T. (2012). Multidrug resistance among new tuberculosis cases: detecting local variation through lot quality-assurance sampling. Epidemiology (Cambridge, Mass.), 23(2)

Cohen T, van Helden PD, Wilson D, Colijn C, McLaughlin MM, Abubakar I, Warren RM. (2012). Mixed-strain mycobacterium tuberculosis infections and the implications for tuberculosis treatment and control. Clinical microbiology reviews, 25(4)

Cohen T, Manjourides J, Hedt-Gauthier B. (2012). Linking surveillance with action against drug-resistant tuberculosis. American journal of respiratory and critical care medicine, 186(5)

Manjourides J, Lin HH, Shin S, Jeffery C, Contreras C, Cruz JS, Jave O, Yagui M, Asencios L, Pagano M, Cohen T. (2012). Identifying multidrug resistant tuberculosis transmission hotspots using routinely collected data. Tuberculosis (Edinburgh, Scotland), 92(3)

Jenkins HE, Zignol M, Cohen T. (2011). Quantifying the burden and trends of isoniazid resistant tuberculosis, 1994-2009. PLoS One, 6(7)

Cohen T, Corbett EL. (2011). Test and treat in HIV: success could depend on rapid detection. Lancet (London, England), 378(9787)

Yaesoubi R, Cohen T. (2011). Generalized Markov Models of Infectious Disease Spread: A Novel Framework for Developing Dynamic Health Policies. European journal of operational research, 215(3)

Sergeev R, Colijn C, Cohen T. (2011). Models to understand the population-level impact of mixed strain M. tuberculosis infections. Journal of theoretical biology, 280(1)

Yaesoubi R, Cohen T. (2011). Dynamic health policies for controlling the spread of emerging infections: influenza as an example. PLoS One, 6(9)

Cohen T. (2011). Staffing metrics: a case study. Biomedical instrumentation & technology, 45(4)

Cohen T, Murray M, Abubakar I, Zhang Z, Sloutsky A, Arteaga F, Chalco K, Franke MF, Becerra MC. (2011). Multiple introductions of multidrug-resistant tuberculosis into households, Lima, Peru. Emerging infectious diseases, 17(6)

Cohen T, Wilson D, Wallengren K, Samuel EY, Murray M. (2011). Mixed-strain Mycobacterium tuberculosis infections among patients dying in a hospital in KwaZulu-Natal, South Africa. Journal of clinical microbiology, 49(1)

Hedt BL, Laufer MK, Cohen T. (2011). Drug resistance surveillance in resource-poor settings: current methods and considerations for TB, HIV, and malaria. The American journal of tropical medicine and hygiene, 84(2)

Cohen T, Murray M, Wallengren K, Alvarez GG, Samuel EY, Wilson D. (2010). The prevalence and drug sensitivity of tuberculosis among patients dying in hospital in KwaZulu-Natal, South Africa: a postmortem study. PLoS medicine, 7(6)

Cohen T, Hedt BL, Pagano M. (2010). Estimating the magnitude and direction of bias in tuberculosis drug resistance surveys conducted only in the public sector: a simulation study. BMC Public Health

Lipsitch M, Tchetgen Tchetgen E, Cohen T. (2010). Negative controls: a tool for detecting confounding and bias in observational studies. Epidemiology (Cambridge, Mass.), 21(3)

Shin SS, Keshavjee S, Gelmanova IY, Atwood S, Franke MF, Mishustin SP, Strelis AK, Andreev YG, Pasechnikov AD, Barnashov A, Tonkel TP, Cohen T. (2010). Development of extensively drug-resistant tuberculosis during multidrug-resistant tuberculosis treatment. American journal of respiratory and critical care medicine, 182(3)

Cohen T. (2010). AAMI's benchmarking solution: analysis of cost of service ratio and other metrics. Biomedical instrumentation & technology, 44(4)

Cohen T, Dye C, Colijn C, Williams B, Murray M. (2009). Mathematical models of the epidemiology and control of drug-resistant TB. Expert review of respiratory medicine, 3(1)

Cohen T, Colijn C, Murray M. (2008). Modeling the effects of strain diversity and mechanisms of strain competition on the potential performance of new tuberculosis vaccines. Proceedings of the National Academy of Sciences of the United States of America, 105(42)

Cohen T, Colijn C, Wright A, Zignol M, Pym A, Murray M. (2008). Challenges in estimating the total burden of drug-resistant tuberculosis. American journal of respiratory and critical care medicine, 177(12)

Cohen T, Colijn C, Finklea B, Wright A, Zignol M, Pym A, Murray M. (2008). Are survey-based estimates of the burden of drug resistant TB too low? Insight from a simulation study. PLoS One, 3(6)

Cohen T, Lipsitch M. (2008). Too little of a good thing: a paradox of moderate infection control. Epidemiology (Cambridge, Mass.), 19(4)

Cohen T, Colijn C, Finklea B, Murray M. (2007). Exogenous re-infection and the dynamics of tuberculosis epidemics: local effects in a network model of transmission. Journal of the Royal Society, Interface, 4(14)

Cohen T, Lipsitch M, Walensky RP, Murray M. (2006). Beneficial and perverse effects of isoniazid preventive therapy for latent tuberculosis infection in HIV-tuberculosis coinfected populations. Proceedings of the National Academy of Sciences of the United States of America, 103(18)

Cohen T, Ellis WS, Morrissey JJ, Bakuzonis C, David Y, Paperman WD. (2005). Safe use of cellular telephones in hospitals: fundamental principles and case studies. Journal of healthcare information management : JHIM, 19(4)

Bageris A, Cohen T. (2005). Maternal hypertension and neonatal outcome among small for gestational age infants. Obstetrics and gynecology, 106(6)

Cohen T, Murray M. (2005). Incident tuberculosis among recent US immigrants and exogenous reinfection. Emerging infectious diseases, 11(5)

Cohen T, Murray M. (2004). Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness. Nature medicine, 10(10)

Cohen T. (2004). Medical and information technologies converge. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society, 23(3)

Cohen T, Becerra MC, Murray MB. (2004). Isoniazid resistance and the future of drug-resistant tuberculosis. Microbial drug resistance (Larchmont, N.Y.), 10(4)

Cohen T. (2003). The future of clinical engineering: technology that enables improved patient care. Biomedical instrumentation & technology, 37(2)

Cohen T, Sommers B, Murray M. (2003). The effect of drug resistance on the fitness of Mycobacterium tuberculosis. The Lancet. Infectious diseases, 3(1)

Cohen T. (2003). Striving for "end-to-end" knowledge to support networked medical systems. Biomedical instrumentation & technology

Cohen T. (2002). Leadership challenges in clinical and information technology services. Biomedical instrumentation & technology, 36(2)