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Trevor Bedford

Associate Member

Education

Affiliations

Projects

Papers

Black A, MacCannell DR, Sibley TR, Bedford T. (2020). Ten recommendations for supporting open pathogen genomic analysis in public health. Nature medicine

Moncla LH, Bedford T, Dussart P, Horm SV, Rith S, Buchy P, Karlsson EA, Li L, Liu Y, Zhu H, Guan Y, Friedrich TC, Horwood PF. (2020). Quantifying within-host diversity of H5N1 influenza viruses in humans and poultry in Cambodia. PLoS pathogens, 16(1)

Jackson Michael L, Hart Gregory R, McCulloch Denise J, Adler Amanda, Brandstetter Elisabeth, Fay Kairsten, Han Peter, Lacombe Kirsten, Lee Jover, Sibley Thomas, Nickerson Deborah A, Rieder Mark, Starita Lea, Englund Janet A, Bedford Trevor, Chu Helen, Famulare Michael, Investigators the Seattle Flu Study. (2020). Effects of weather-related social distancing on city-scale transmission of respiratory viruses. Cold Spring Harbor Laboratory Press

Soh YS, Moncla LH, Eguia R, Bedford T, Bloom JD. (2019). Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans. eLife, (8)

Bell SM, Katzelnick L, Bedford T. (2019). Dengue genetic divergence generates within-serotype antigenic variation, but serotypes dominate evolutionary dynamics. Elife, (8)

Neher RA, Bedford T. (2018). Real-Time Analysis and Visualization of Pathogen Sequence Data. Journal of Clinical Microbiology, 56(11)

Hadfield J, Megill C, Bell SM, Huddleston J, Potter B, Callender C, Sagulenko P, Bedford T, Neher RA. (2018). Nextstrain: real-time tracking of pathogen evolution. Bioinformatics (Oxford, England), 34(23)

Dudas G, Carvalho LM, Rambaut A, Bedford T. (2018). Correction: MERS-CoV spillover at the camel-human interface. Elife, (7)

Wen FT, Bell SM, Bedford T, Cobey S. (2018). Estimating Vaccine-Driven Selection in Seasonal Influenza. Viruses, 10(9), https://github.com/cobeylab/flu-vaccine-sieve

Dudas G, Carvalho LM, Rambaut A, Bedford T. (2018). MERS-CoV spillover at the camel-human interface. eLife, (7)

Xue KS, Moncla LH, Bedford T, Bloom JD. (2018). Within-Host Evolution of Human Influenza Virus. Trends in microbiology, 26(9)

Lee JM, Huddleston J, Doud MB, Hooper KA, Wu NC, Bedford T, Bloom JD. (2018). Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants. Proceedings of the National Academy of Sciences of the United States of America, 115(35)

Quick J, Grubaugh ND, Pullan ST, Claro IM, Smith AD, Gangavarapu K, Oliveira G, Robles-Sikisaka R, Rogers TF, Beutler NA, Burton DR, Lewis-Ximenez LL, de Jesus JG, Giovanetti M, Hill SC, Black A, Bedford T, Carroll MW, Nunes M, Alcantara LC Jr., Sabino EC, Baylis SA, Faria NR, Loose M, Simpson JT, Pybus OG, Andersen KG, Loman NJ. (2017). Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples. Nature protocols, 12(6)

Grubaugh ND, Ladner JT, Kraemer MUG, Dudas G, Tan AL, Gangavarapu K, Wiley MR, White S, Thézé J, Magnani DM, Prieto K, Reyes D, Bingham AM, Paul LM, Robles-Sikisaka R, Oliveira G, Pronty D, Barcellona CM, Metsky HC, Baniecki ML, Barnes KG, Chak B, Freije CA, Gladden-Young A, Gnirke A, Luo C, MacInnis B, Matranga CB, Park DJ, Qu J, Schaffner SF, Tomkins-Tinch C, West KL, Winnicki SM, Wohl S, Yozwiak NL, Quick J, Fauver JR, Khan K, Brent SE, Reiner RC Jr., Lichtenberger PN, Ricciardi MJ, Bailey VK, Watkins DI, Cone MR, Kopp EW 4th., Hogan KN, Cannons AC, Jean R, Monaghan AJ, Garry RF, Loman NJ, Faria NR, Porcelli MC, Vasquez C, Nagle ER, Cummings DAT, Stanek D, Rambaut A, Sanchez-Lockhart M, Sabeti PC, Gillis LD, Michael SF, Bedford T, Pybus OG, Isern S, Palacios G, Andersen KG. (2017). Genomic epidemiology reveals multiple introductions of Zika virus into the United States. Nature, 546(7658)

Dudas G, Carvalho LM, Bedford T, Tatem AJ, Baele G, Faria NR, Park DJ, Ladner JT, Arias A, Asogun D, Bielejec F, Caddy SL, Cotten M, D'Ambrozio J, Dellicour S, Di Caro A, Diclaro JW, Duraffour S, Elmore MJ, Fakoli LS, Faye O, Gilbert ML, Gevao SM, Gire S, Gladden-Young A, Gnirke A, Goba A, Grant DS, Haagmans BL, Hiscox JA, Jah U, Kugelman JR, Liu D, Lu J, Malboeuf CM, Mate S, Matthews DA, Matranga CB, Meredith LW, Qu J, Quick J, Pas SD, Phan MVT, Pollakis G, Reusken CB, Sanchez-Lockhart M, Schaffner SF, Schieffelin JS, Sealfon RS, Simon-Loriere E, Smits SL, Stoecker K, Thorne L, Tobin EA, Vandi MA, Watson SJ, West K, Whitmer S, Wiley MR, Winnicki SM, Wohl S, Wölfel R, Yozwiak NL, Andersen KG, Blyden SO, Bolay F, Carroll MW, Dahn B, Diallo B, Formenty P, Fraser C, Gao GF, Garry RF, Goodfellow I, Günther S, Happi CT, Holmes EC, Kargbo B, Keïta S, Kellam P, Koopmans MPG, Kuhn JH, Loman NJ, Magassouba N, Naidoo D, Nichol ST, Nyenswah T, Palacios G, Pybus OG, Sabeti PC, Sall A, Ströher U, Wurie I, Suchard MA, Lemey P, Rambaut A. (2017). Virus genomes reveal factors that spread and sustained the Ebola epidemic. Nature, 544(7650)

Morris DH, Gostic KM, Pompei S, Bedford T, Łuksza M, Neher RA, Grenfell BT, Lässig M, McCauley JW. (2018). Predictive Modeling of Influenza Shows the Promise of Applied Evolutionary Biology. Trends in microbiology, 26(2)

Bell SM, Bedford T. (2017). Modern-day SIV viral diversity generated by extensive recombination and cross-species transmission. PLoS Pathogens, 13(7)

Langat P, Raghwani J, Dudas G, Bowden TA, Edwards S, Gall A, Bedford T, Rambaut A, Daniels RS, Russell CA, Pybus OG, McCauley J, Kellam P, Watson SJ. (2017). Genome-wide evolutionary dynamics of influenza B viruses on a global scale. PLoS pathogens, 13(12)

Lorenzo-Redondo R, Fryer HR, Bedford T, Kim EY, Archer J, Pond SLK, Chung YS, Penugonda S, Chipman J, Fletcher CV, Schacker TW, Malim MH, Rambaut A, Haase AT, McLean AR, Wolinsky SM. (2016). Persistent HIV-1 replication maintains the tissue reservoir during therapy. Nature, 530(7588)

Wen F, Bedford T, Cobey S. (2016). Explaining the geographical origins of seasonal influenza A (H3N2). Proceedings. Biological sciences, 283(1838)

Lipsitch M, Barclay W, Raman R, Russell CJ, Belser JA, Cobey S, Kasson PM, Lloyd-Smith JO, Maurer-Stroh S, Riley S, Beauchemin CA, Bedford T, Friedrich TC, Handel A, Herfst S, Murcia PR, Roche B, Wilke CO, Russell CA. (2016). Viral factors in influenza pandemic risk assessment. Elife, (5)

Neher RA, Bedford T, Daniels RS, Russell CA, Shraiman BI. (2016). Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses. Proceedings of the National Academy of Sciences of the United States of America, 113(12)

Bedford T, Malik HS. (2016). Did a Single Amino Acid Change Make Ebola Virus More Virulent. Cell, 167(4)

Karcher MD, Palacios JA, Bedford T, Suchard MA, Minin VN. (2016). Quantifying and Mitigating the Effect of Preferential Sampling on Phylodynamic Inference. PLoS computational biology, 12(3)

Harvey WT, Benton DJ, Gregory V, Hall JP, Daniels RS, Bedford T, Haydon DT, Hay AJ, McCauley JW, Reeve R. (2016). Identification of Low- and High-Impact Hemagglutinin Amino Acid Substitutions That Drive Antigenic Drift of Influenza A(H1N1) Viruses. PLoS pathogens, 12(4)

Black A, Breyta R, Bedford T, Kurath G. (2016). Geography and host species shape the evolutionary dynamics of U genogroup infectious hematopoietic necrosis virus. Virus evolution, 2(2)

Neher RA, Bedford T. (2015). nextflu: real-time tracking of seasonal influenza virus evolution in humans. Bioinformatics (Oxford, England), 31(21)

Machkovech HM, Bedford T, Suchard MA, Bloom JD. (2015). Positive Selection in CD8+ T-Cell Epitopes of Influenza Virus Nucleoprotein Revealed by a Comparative Analysis of Human and Swine Viral Lineages. Journal of virology, 89(22)

Park DJ, Dudas G, Wohl S, Goba A, Whitmer SL, Andersen KG, Sealfon RS, Ladner JT, Kugelman JR, Matranga CB, Winnicki SM, Qu J, Gire SK, Gladden-Young A, Jalloh S, Nosamiefan D, Yozwiak NL, Moses LM, Jiang PP, Lin AE, Schaffner SF, Bird B, Towner J, Mamoh M, Gbakie M, Kanneh L, Kargbo D, Massally JL, Kamara FK, Konuwa E, Sellu J, Jalloh AA, Mustapha I, Foday M, Yillah M, Erickson BR, Sealy T, Blau D, Paddock C, Brault A, Amman B, Basile J, Bearden S, Belser J, Bergeron E, Campbell S, Chakrabarti A, Dodd K, Flint M, Gibbons A, Goodman C, Klena J, McMullan L, Morgan L, Russell B, Salzer J, Sanchez A, Wang D, Jungreis I, Tomkins-Tinch C, Kislyuk A, Lin MF, Chapman S, MacInnis B, Matthews A, Bochicchio J, Hensley LE, Kuhn JH, Nusbaum C, Schieffelin JS, Birren BW, Forget M, Nichol ST, Palacios GF, Ndiaye D, Happi C, Gevao SM, Vandi MA, Kargbo B, Holmes EC, Bedford T, Gnirke A, Ströher U, Rambaut A, Garry RF, Sabeti PC. (2015). Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone. Cell, 161(7)

Bedford T, Riley S, Barr IG, Broor S, Chadha M, Cox NJ, Daniels RS, Gunasekaran CP, Hurt AC, Kelso A, Klimov A, Lewis NS, Li X, McCauley JW, Odagiri T, Potdar V, Rambaut A, Shu Y, Skepner E, Smith DJ, Suchard MA, Tashiro M, Wang D, Xu X, Lemey P, Russell CA. (2015). Global circulation patterns of seasonal influenza viruses vary with antigenic drift. Nature, 523(7559)

Frost SD, Pybus OG, Gog JR, Viboud C, Bonhoeffer S, Bedford T. (2015). Eight challenges in phylodynamic inference. Epidemics, (10)

Bedford T, Suchard MA, Lemey P, Dudas G, Gregory V, Hay AJ, McCauley JW, Russell CA, Smith DJ, Rambaut A. (2014). Integrating influenza antigenic dynamics with molecular evolution. Elife, (3)

Roche B, Drake JM, Brown J, Stallknecht DE, Bedford T, Rohani P. (2014). Adaptive evolution and environmental durability jointly structure phylodynamic patterns in avian influenza viruses. PLoS biology, 12(8)

Volz EM, Koelle K, Bedford T. (2013). Viral phylodynamics. PLoS computational biology, 9(3)

Landis MJ, Bedford T. (2014). Phylowood: interactive web-based animations of biogeographic and phylogeographic histories. Bioinformatics (Oxford, England), 30(1)

Bedford T, Rambaut A, Pascual M. (2012). Canalization of the evolutionary trajectory of the human influenza virus. BMC biology, (10)

Bedford T, Cobey S, Pascual M. (2011). Strength and tempo of selection revealed in viral gene genealogies. BMC evolutionary biology, (11)

Bedford T, Cobey S, Beerli P, Pascual M. (2010). Global migration dynamics underlie evolution and persistence of human influenza A (H3N2). PLoS pathogens, 6(5)

Bedford T, Hartl DL. (2009). Optimization of gene expression by natural selection. Proceedings of the National Academy of Sciences of the United States of America, 106(4)

Bedford T, Wapinski I, Hartl DL. (2008). Overdispersion of the molecular clock varies between yeast, Drosophila and mammals. Genetics, 179(2)

Bedford T, Hartl DL. (2008). Overdispersion of the molecular clock: temporal variation of gene-specific substitution rates in Drosophila. Molecular biology and evolution, 25(8)