Optimizing cervical cancer screening for women living with HIV in the United States.


Cervical cancer is preventable with screening and treatment, but late diagnosis contributes to elevated incidence and mortality among women living with HIV (WLHIV) in the US. This project seeks to evaluate novel strategies to optimize cervical cancer screening in this population with three specific aims: (1) Assess the feasibility, acceptability, and clinical performance of self-collected human papillomavirus (HPV) DNA testing for cervical cancer screening, (2) Develop a clinical risk score to inform risk-stratified screening algorithms, (3) Develop a mathematical model to evaluate the effectiveness and cost-effectiveness of risk-stratified screening in women living with HIV. The results will inform clinical practice and may increase screening coverage and decrease unnecessary medical procedures for this high-risk population.


Funding Source

National Center For Advancing Translational Sciences

Project Period