University of California San Francisco
We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. While the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs.
Arzika AM, Maliki R, Abdou A, Mankara AK, Harouna AN, Cook C, Hinterwirth A, Worden L, Zhong L, Chen C, Ruder K, Zhou Z, Lebas E, O'Brien KS, Oldenburg CE, Le V, Arnold BF, Porco T, Keenan JD, Lietman TM, Doan T. (2021). Gut resistome of preschool children after prolonged mass azithromycin distribution: a cluster-randomized trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America