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Michael Mina

Chief Science Officer

Education

Affiliations

Projects

Papers

Bjornevik K, Cortese M, Healy BC, Kuhle J, Mina MJ, Leng Y, Elledge SJ, Niebuhr DW, Scher AI, Munger KL, Ascherio A. (2022). Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science (New York, N.Y.)

Regev-Yochay G, Kriger O, Mina MJ, Beni S, Rubin C, Mechnik B, Hason S, Biber E, Nadaf B, Kreiss Y, Amit S. (2022). Real World Performance of SARS-CoV-2 Antigen Rapid Diagnostic Tests in Various Clinical Settings. Infection control and hospital epidemiology

Saad-Roy CM, Morris SE, Metcalf CJE, Mina MJ, Baker RE, Farrar J, Holmes EC, Pybus OG, Graham AL, Levin SA, Grenfell BT, Wagner CE. (2021). Partial immunity and SARS-CoV-2 mutations-Response. Science (New York, N.Y.), 372(6540)

Cleary B, Hay JA, Blumenstiel B, Harden M, Cipicchio M, Bezney J, Simonton B, Hong D, Senghore M, Sesay AK, Gabriel S, Regev A, Mina MJ. (2021). Using viral load and epidemic dynamics to optimize pooled testing in resource-constrained settings. Science translational medicine

Wagner CE, Saad-Roy CM, Morris SE, Baker RE, Mina MJ, Farrar J, Holmes EC, Pybus OG, Graham AL, Emanuel EJ, Levin SA, Metcalf CJE, Grenfell BT. (2021). Vaccine nationalism and the dynamics and control of SARS-CoV-2. Science (New York, N.Y.)

Mina MJ, Peto TE, García-Fiñana M, Semple MG, Buchan IE. (2021). Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19. Lancet

Petersen I, Crozier A, Buchan I, Mina MJ, Bartlett JW. (2021). Recalibrating SARS-CoV-2 Antigen Rapid Lateral Flow Test Relative Sensitivity from Validation Studies to Absolute Sensitivity for Indicating Individuals Shedding Transmissible Virus. Clinical epidemiology, (13)

Hay JA, Kennedy-Shaffer L, Kanjilal S, Lennon NJ, Gabriel SB, Lipsitch M, Mina MJ. (2021). Estimating epidemiologic dynamics from cross-sectional viral load distributions. medRxiv : the preprint server for health sciences

Lennon NJ, Bhattacharyya RP, Mina MJ, Rehm HL, Hung DT, Smole S, Woolley A, Lander ES, Gabriel SB. (2021). Cross-sectional assessment of SARS-CoV-2 viral load by symptom status in Massachusetts congregate living facilities. The Journal of infectious diseases

Goudsmit J, van den Biggelaar AHJ, Koudstaal W, Hofman A, Koff WC, Schenkelberg T, Alter G, Mina MJ, Wu JW. (2021). Immune age and biological age as determinants of vaccine responsiveness among elderly populations: the Human Immunomics Initiative research program. European journal of epidemiology

Menkir TF, Chin T, Hay JA, Surface ED, De Salazar PM, Buckee CO, Watts A, Khan K, Sherbo R, Yan AWC, Mina MJ, Lipsitch M, Niehus R. (2021). Estimating internationally imported cases during the early COVID-19 pandemic. Nature communications, 12(1)

Martinón-Torres F, García-Sastre A, Pollard AJ, Martín C, Osterhaus A, Ladhani SN, Ramilo O, Gómez Rial J, Salas A, Bosch FX, Martinón-Torres M, Mina MJ, Cherry J. (2021). TIPICO XI: report of the first series and podcast on infectious diseases and vaccines (aTIPICO). Human vaccines & immunotherapeutics

Saad-Roy CM, Morris SE, Metcalf CJE, Mina MJ, Baker RE, Farrar J, Holmes EC, Pybus OG, Graham AL, Levin SA, Grenfell BT, Wagner CE. (2021). Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes. Science (New York, N.Y.)

Biering SB, Akey DL, Wong MP, Brown WC, Lo NTN, Puerta-Guardo H, Tramontini Gomes de Sousa F, Wang C, Konwerski JR, Espinosa DA, Bockhaus NJ, Glasner DR, Li J, Blanc SF, Juan EY, Elledge SJ, Mina MJ, Beatty PR, Smith JL, Harris E. (2021). Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction. Science (New York, N.Y.), 371(6525)

Mina MJ, Andersen KG. (2021). COVID-19 testing: One size does not fit all. Science (New York, N.Y.), 371(6525)

Kahn R, Holmdahl I, Reddy S, Jernigan J, Mina MJ, Slayton RB. (2021). Mathematical modeling to inform vaccination strategies and testing approaches for COVID-19 in nursing homes. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Aatresh AV, Cummings K, Gerstein H, Knight CS, Limberopolous A, Stasi MA, Bedugnis A, Somberg KA, França CT, Mina MJ. (2021). Development of at-home sample collection logistics for large-scale seroprevalence studies. PloS one, 16(11)

Holmdahl I, Kahn R, Hay JA, Buckee CO, Mina MJ. (2021). Estimation of Transmission of COVID-19 in Simulated Nursing Homes With Frequent Testing and Immunity-Based Staffing. JAMA network open, 4(5)

Hay JA, Kennedy-Shaffer L, Kanjilal S, Lennon NJ, Gabriel SB, Lipsitch M, Mina MJ. (2021). Estimating epidemiologic dynamics from cross-sectional viral load distributions. Science (New York, N.Y.)

Saad-Roy CM, Morris SE, Metcalf CJE, Mina MJ, Baker RE, Farrar J, Holmes EC, Pybus OG, Graham AL, Levin SA, Grenfell BT, Wagner CE. (2021). Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes. medRxiv : the preprint server for health sciences

Kahn R, Holmdahl I, Reddy S, Jernigan J, Mina MJ, Slayton RB. (2021). Mathematical modeling to inform vaccination strategies and testing approaches for COVID-19 in nursing homes. medRxiv : the preprint server for health sciences

Larremore DB, Wilder B, Lester E, Shehata S, Burke JM, Hay JA, Tambe M, Mina MJ, Parker R. (2020). Test sensitivity is secondary to frequency and turnaround time for COVID-19 surveillance. medRxiv : the preprint server for health sciences

Lipsitch M, Kahn R, Mina MJ. (2020). Antibody testing will enhance the power and accuracy of COVID-19-prevention trials. Nature medicine

Menkir TF, Chin T, Hay J, Surface ED, De Salazar PM, Buckee CO, Watts A, Khan K, Sherbo R, Yan AWC, Mina M, Lipsitch M, Niehus R. (2020). Estimating the number of undetected COVID-19 cases exported internationally from all of China. medRxiv : the preprint server for health sciences

Tom MR, Mina MJ. (2020). To Interpret the SARS-CoV-2 Test, Consider the Cycle Threshold Value. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71(16)

Saad-Roy CM, Wagner CE, Baker RE, Morris SE, Farrar J, Graham AL, Levin SA, Mina MJ, Metcalf CJE, Grenfell BT. (2020). Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 years. Science (New York, N.Y.)

Larremore DB, Wilder B, Lester E, Shehata S, Burke JM, Hay JA, Tambe M, Mina MJ, Parker R. (2020). Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening. Science advances

Bryant JE, Azman AS, Ferrari MJ, Arnold BF, Boni MF, Boum Y, Hayford K, Luquero FJ, Mina MJ, Rodriguez-Barraquer I, Wu JT, Wade D, Vernet G, Leung DT. (2020). Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward. Science immunology, 5(47)

Clapham H, Hay J, Routledge I, Takahashi S, Choisy M, Cummings D, Grenfell B, Metcalf CJE, Mina M, Barraquer IR, Salje H, Tam CC. (2020). Seroepidemiologic Study Designs for Determining SARS-COV-2 Transmission and Immunity. Emerging infectious diseases, 26(9)

Mina MJ, Guterman LB, Allen KE, Omer SB. (2020). Comprehensive Profiling of Zika Virus Risk with Natural and Artificial Mitigating Strategies, United States. Emerging infectious diseases, 26(4)

Walker MR, Eltahla AA, Mina MM, Li H, Lloyd AR, Bull RA. (2020). Envelope-Specific IgG3 and IgG1 Responses Are Associated with Clearance of Acute Hepatitis C Virus Infection. Viruses, 12(1)

Mina MJ, Metcalf CJE, McDermott AB, Douek DC, Farrar J, Grenfell BT. (2020). A Global lmmunological Observatory to meet a time of pandemics. eLife, (9)

Cleary B, Hay JA, Blumenstiel B, Harden M, Cipicchio M, Bezney J, Simonton B, Hong D, Senghore M, Sesay AK, Gabriel S, Regev A, Mina MJ. (2020). Efficient prevalence estimation and infected sample identification with group testing for SARS-CoV-2. medRxiv : the preprint server for health sciences

Yang L, Grenfell BT, Mina MJ. (2020). Waning immunity and re-emergence of measles and mumps in the vaccine era. Current opinion in virology, (40)

Mina MJ, Parker R, Larremore DB. (2020). Rethinking Covid-19 Test Sensitivity - A Strategy for Containment. The New England journal of medicine, 383(22)

Harrison GF, Sanz J, Boulais J, Mina MJ, Grenier JC, Leng Y, Dumaine A, Yotova V, Bergey CM, Nsobya SL, Elledge SJ, Schurr E, Quintana-Murci L, Perry GH, Barreiro LB. (2019). Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists. Nature ecology & evolution, 3(8)

Rylance J, de Steenhuijsen Piters WAA, Mina MJ, Bogaert D, French N, Ferreira DM, . (2019). Two Randomized Trials of the Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization. American journal of respiratory and critical care medicine, 199(9)

Mina MJ, Grenfell BT, Metcalf CJE. (2019). Response to Comment on "Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality". Science (New York, N.Y.), 365(6449)

Kanjilal S, Mina MJ. (2019). Passive immunity for the treatment of influenza: quality not quantity. The Lancet. Respiratory medicine, 7(11)

Mina MJ, Kula T, Leng Y, Li M, de Vries RD, Knip M, Siljander H, Rewers M, Choy DF, Wilson MS, Larman HB, Nelson AN, Griffin DE, de Swart RL, Elledge SJ. (2019). Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. Science (New York, N.Y.), 366(6465)

Yang L, Grenfell BT, Mina MJ. (2019). Measles vaccine immune escape: Should we be concerned?. European journal of epidemiology, 34(10)

Gadroen K, Dodd CN, Masclee GMC, de Ridder MAJ, Weibel D, Mina MJ, Grenfell BT, Sturkenboom MCJM, van de Vijver DAMC, de Swart RL. (2018). Impact and longevity of measles-associated immune suppression: a matched cohort study using data from the THIN general practice database in the UK. BMJ open, 8(11)

Morris SE, Yates AJ, de Swart RL, de Vries RD, Mina MJ, Nelson AN, Lin WW, Kouyos RD, Griffin DE, Grenfell BT. (2018). Modeling the measles paradox reveals the importance of cellular immunity in regulating viral clearance. PLoS pathogens, 14(12)

Mina MJ. (2017). Measles, immune suppression and vaccination: direct and indirect nonspecific vaccine benefits. The Journal of infection, (74 Suppl 1)

Mina MJ. (2017). Generalized herd effects and vaccine evaluation: impact of live influenza vaccine on off-target bacterial colonisation. The Journal of infection, (74 Suppl 1)

Herfst S, Böhringer M, Karo B, Lawrence P, Lewis NS, Mina MJ, Russell CJ, Steel J, de Swart RL, Menge C. (2017). Drivers of airborne human-to-human pathogen transmission. Current opinion in virology, (22)

Mina MM, Herawati L, Butler T, Lloyd A. Hepatitis C in Australian prisons: a national needs assessment. International journal of prisoner health, 12(1)

Mina MJ, Brown LA, Klugman KP. (2015). Dynamics of Increasing IFN-γ Exposure on Murine MH-S Cell-Line Alveolar Macrophage Phagocytosis of Streptococcus pneumoniae. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 35(6)

Mina MM, Luciani F, Cameron B, Bull RA, Beard MR, Booth D, Lloyd AR. (2015). Resistance to hepatitis C virus: potential genetic and immunological determinants. The Lancet. Infectious diseases, 15(4)

Mina MJ, Metcalf CJ, de Swart RL, Osterhaus AD, Grenfell BT. (2015). Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality. Science (New York, N.Y.), 348(6235)

Birger RB, Kouyos RD, Cohen T, Griffiths EC, Huijben S, Mina MJ, Volkova V, Grenfell B, Metcalf CJE. (2015). The potential impact of coinfection on antimicrobial chemotherapy and drug resistance. Trends in microbiology, 23(9)

Birger RB, Kouyos RD, Cohen T, Griffiths EC, Huijben S, Mina MJ, Volkova V, Grenfell B, Metcalf CJE. (2015). Erratum to: 'The potential impact of coinfection on antimicrobial chemotherapy and drug resistance'. Trends in microbiology, 23(11)

Sugden PB, Cameron B, Mina M, Lloyd AR, . (2014). Protection against hepatitis C infection via NK cells in highly-exposed uninfected injecting drug users. Journal of hepatology, 61(4)

Mina MM, Clark PJ, Beasley HM, Herawati L, Butler TG, Lloyd AR. (2014). Enhancing hepatitis C treatment in the custodial setting: a national roadmap. The Medical journal of Australia, 200(1)

Mina MJ, Klugman KP. (2014). The role of influenza in the severity and transmission of respiratory bacterial disease. The Lancet. Respiratory medicine, 2(9)

Mina MJ, McCullers JA, Klugman KP. (2014). Live attenuated influenza vaccine enhances colonization of Streptococcus pneumoniae and Staphylococcus aureus in mice. mBio, 5(1)

Mina MJ, Klugman KP, Rosch JW, McCullers JA. (2015). Live attenuated influenza virus increases pneumococcal translocation and persistence within the middle ear. The Journal of infectious diseases, 212(2)

Mina MJ, Klugman KP. (2014). Reply to "no clinical association of live attenuated influenza vaccine with nasal carriage of bacteria or acute otitis media": specific recommendations for future studies. mBio, 5(3)

Rosch JW, Iverson AR, Humann J, Mann B, Gao G, Vogel P, Mina M, Murrah KA, Perez AC, Edward Swords W, Tuomanen EI, McCullers JA. (2014). A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media. EMBO molecular medicine, 6(1)

Chang CC, Crane M, Zhou J, Mina M, Post JJ, Cameron BA, Lloyd AR, Jaworowski A, French MA, Lewin SR. (2013). HIV and co-infections. Immunological reviews, 254(1)

Mina MJ, Klugman KP. (2013). Pathogen replication, host inflammation, and disease in the upper respiratory tract. Infection and immunity, 81(3)

Mina MJ, Klugman KP, McCullers JA. (2013). Live attenuated influenza vaccine, but not pneumococcal conjugate vaccine, protects against increased density and duration of pneumococcal carriage after influenza infection in pneumococcal colonized mice. The Journal of infectious diseases, 208(8)

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