Rui Wang

Associate Professor




Preferred Pronouns

Personal Academic Website

Research/Topics of Interest


Pathogens/Diseases of Main Interest/Expertise


Countries of Work/Collaboration



DeGruttola V, Goyal R, Martin NK, Wang R. (2022). Network methods and design of randomized trials: Application to investigation of COVID-19 vaccination boosters. Clinical trials (London, England)

Zhao YY, Wang R, Gleason KJ, Lewis EF, Quan SF, Toth CM, Song Y, Morrical M, Rueschman M, Mittleman MA, Redline S. (2022). Effect of continuous positive airway pressure treatment on ambulatory blood pressures in high-risk sleep apnea patients: a randomized controlled trial. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Li D, Lu W, Shu D, Toh S, Wang R. (2022). Distributed Cox proportional hazards regression using summary-level information. Biostatistics (Oxford, England)

Longini IM, Yang Y, Fleming TR, Muñoz-Fontela C, Wang R, Ellenberg SS, Qian G, Halloran ME, Nason M, Gruttola V, Mulangu S, Huang Y, Donnelly CA, Henao Restrepo AM. (2022). A platform trial design for preventive vaccines against Marburg virus and other emerging infectious disease threats. Clinical trials (London, England)

Li F, Chen X, Tian Z, Esserman D, Heagerty PJ, Wang R. (2022). Designing three-level cluster randomized trials to assess treatment effect heterogeneity. Biostatistics (Oxford, England)

Sun JW, Wang R, Li D, Toh S. (2022). Use of Linked Databases for Improved Confounding Control: Considerations for Potential Selection Bias. American journal of epidemiology

Wang X, Turner EL, Li F, Wang R, Moyer J, Cook AJ, Murray DM, Heagerty PJ. (2022). Two weights make a wrong: Cluster randomized trials with variable cluster sizes and heterogeneous treatment effects. Contemporary clinical trials, (114)

Li F, Wang R. (2022). Stepped Wedge Cluster Randomized Trials: A Methodological Overview. World neurosurgery, (161)

Gao S, Wu L, Yu T, Kouyos R, Günthard HF, Wang R. (2022). Nonlinear mixed-effects models for HIV viral load trajectories before and after antiretroviral therapy interruption, incorporating left censoring. Statistical communications in infectious diseases, 14(1)

Park J, Park JS, Huang CH, Jo A, Cook K, Wang R, Lin HY, Van Deun J, Li H, Min J, Wang L, Yoon G, Carter BS, Balaj L, Choi GS, Castro CM, Weissleder R, Lee H. (2021). An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma. Nature biomedical engineering

Harrison LJ, Wang R. (2021). Power calculation for analyses of cross-sectional stepped-wedge cluster randomized trials with binary outcomes via generalized estimating equations. Statistics in medicine

Rabideau DJ, Wang R. (2021). Randomization-based inference for a marginal treatment effect in stepped wedge cluster randomized trials. Statistics in medicine

Klompas M, Baker MA, Rhee C, Tucker R, Fiumara K, Griesbach D, Bennett-Rizzo C, Salmasian H, Wang R, Wheeler N, Gallagher GR, Lang AS, Fink T, Baez S, Smole S, Madoff L, Goralnick E, Resnick A, Pearson M, Britton K, Sinclair J, Morris CA. (2021). A SARS-CoV-2 Cluster in an Acute Care Hospital. Annals of internal medicine

Little SJ, Chen T, Wang R, Anderson C, Pond SK, Nakazawa M, Mathews WC, DeGruttola V, Smith DM. (2021). Effective Human Immunodeficiency Virus Molecular Surveillance Requires Identification of Incident Cases of Infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 73(5)

Shu D, Han P, Wang R, Toh S. (2021). Estimating the marginal hazard ratio by simultaneously using a set of propensity score models: A multiply robust approach. Statistics in medicine

Klompas M, Ye S, Vaidya V, Ochoa A, Baker MA, Hopcia K, Hashimoto D, Wang R, Rhee C. (2021). Association between Airborne Infection Isolation Room Utilization Rates and Healthcare Worker COVID-19 Infections in Two Academic Hospitals. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Ganmaa D, Wang R, Willett WC, Manson JE. (2021). Response to the letter to the editor: "The link between Vitamin D and COVID-19". Contemporary clinical trials, (105)

Samartsidis P, Martin NN, De Gruttola V, De Vocht F, Hutchinson S, Lok JJ, Puenpatom A, Wang R, Hickman M, De Angelis D. (2021). Evaluating the power of the causal impact method in observational studies of HCV treatment as prevention. Statistical communications in infectious diseases, 13(1)

Rhee C, Wang R, Ye S, Baker MA, Griesbach D, Laskowski K, Klompas M. (2021). Decline in SARS-CoV-2 Infections Among Health Care Workers at 2 Hospitals Following Rollout and Administration of mRNA Vaccines. Open forum infectious diseases, 8(8)

Rhee C, Yu T, Wang R, Kadri SS, Fram D, Chen HC, Klompas M, . (2021). Association Between Implementation of the Severe Sepsis and Septic Shock Early Management Bundle Performance Measure and Outcomes in Patients With Suspected Sepsis in US Hospitals. JAMA network open, 4(12)

Alrawashdeh M, Rhee C, Hsu H, Wang R, Horan K, Lee GM. (2021). Assessment of Federal Value-Based Incentive Programs and In-Hospital Clostridioides difficile Infection Rates. JAMA network open, 4(10)

Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, Xing X, Xiang N, Wu Y, Li C, Chen Q, Li D, Liu T, Zhao J, Liu M, Tu W, Chen C, Jin L, Yang R, Wang Q, Zhou S, Wang R, Liu H, Luo Y, Liu Y, Shao G, Li H, Tao Z, Yang Y, Deng Z, Liu B, Ma Z, Zhang Y, Shi G, Lam TTY, Wu JT, Gao GF, Cowling BJ, Yang B, Leung GM, Feng Z. (2020). Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. The New England journal of medicine

Vinegoni C, Fumene Feruglio P, Courties G, Schmidt S, Hulsmans M, Lee S, Wang R, Sosnovik D, Nahrendorf M, Weissleder R. (2020). Fluorescence microscopy tensor imaging representations for large-scale dataset analysis. Scientific reports, 10(1)

Cook K, Wang R. (2020). Estimation of conditional power for cluster-randomized trials with interval-censored endpoints. Biometrics

Zhao L, Chen T, Novitsky V, Wang R. (2020). Joint penalized spline modeling of multivariate longitudinal data, with application to HIV-1 RNA load levels and CD4 cell counts. Biometrics

Chen T, Wang R. (2020). Inference for variance components in linear mixed-effect models with flexible random effect and error distributions. Statistical methods in medical research, 29(12)

Wang R, Bing A, Wang C, Hu Y, Bosch RJ, DeGruttola V. (2020). A flexible nonlinear mixed effects model for HIV viral load rebound after treatment interruption. Statistics in medicine, 39(15)

Wang R, Hacker MR, Richardson M. (2020). Cost-effectiveness of Surgical Treatment Pathways for Prolapse. Female pelvic medicine & reconstructive surgery

Shu D, Young JG, Toh S, Wang R. (2020). Variance estimation in inverse probability weighted Cox models. Biometrics

Nguyen DD, Gao K, Chen J, Wang R, Wei GW. (2020). Potentially highly potent drugs for 2019-nCoV. bioRxiv : the preprint server for biology

Zeng S, Li F, Wang R, Li F. (2021). Propensity score weighting for covariate adjustment in randomized clinical trials. Statistics in medicine, 40(4)

Ogburn EL, Bierer BE, Brookmeyer R, Choirat C, Dean NE, De Gruttola V, Ellenberg SS, Halloran ME, Hanley DF Jr., Lee JK, Wang R, Scharfstein DO. (2020). Aggregating data from COVID-19 trials. Science (New York, N.Y.), 368(6496)

Wang R, DeGruttola V, Lei Q, Mayer KH, Redline S, Hazra A, Mora S, Willett WC, Ganmaa D, Manson JE. (2020). The vitamin D for COVID-19 (VIVID) trial: A pragmatic cluster-randomized design. Contemporary clinical trials, (100)

Song Y, Sun F, Redline S, Wang R. (2020). Random-effects meta-analysis of combined outcomes based on reconstructions of individual patient data. Research synthesis methods, 11(5)

Caroff DA, Wang R, Zhang Z, Wolf R, Septimus E, Harris AD, Jackson SS, Poland RE, Hickok J, Huang SS, Platt R. (2020). The Limited Utility of Ranking Hospitals Based on Their Colon Surgery Infection Rates. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Chen T, Tchetgen EJT, Wang R. (2020). A stochastic second-order generalized estimating equations approach for estimating association parameters. Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America, 29(3)

Hsu HE, Mathew R, Wang R, Broadwell C, Horan K, Jin R, Rhee C, Lee GM. (2020). Health Care-Associated Infections Among Critically Ill Children in the US, 2013-2018. JAMA pediatrics

Dean NE, Gsell PS, Brookmeyer R, Crawford FW, Donnelly CA, Ellenberg SS, Fleming TR, Halloran ME, Horby P, Jaki T, Krause PR, Longini IM, Mulangu S, Muyembe-Tamfum JJ, Nason MC, Smith PG, Wang R, Henao-Restrepo AM, De Gruttola V. (2020). Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks. The New England journal of medicine, 382(14)

Rhee C, Kadri SS, Dekker JP, Danner RL, Chen HC, Fram D, Zhang F, Wang R, Klompas M, . (2020). Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use. JAMA network open, 3(4)

Wirth KE, Gaolathe T, Pretorius Holme M, Mmalane M, Kadima E, Chakalisa U, Manyake K, Matildah Mbikiwa A, Simon SV, Letlhogile R, Mukokomani K, van Widenfelt E, Moyo S, Bennett K, Leidner J, Powis KM, Lebelonyane R, Alwano MG, Jarvis J, Dryden-Peterson SL, Kgathi C, Moore J, Bachanas P, Raizes E, Abrams W, Block L, Sento B, Novitsky V, El-Halabi S, Marukutira T, Mills LA, Sexton C, Pals S, Shapiro RL, Wang R, Lei Q, DeGruttola V, Makhema J, Essex M, Lockman S, Tchetgen Tchetgen EJ. (2020). Population uptake of HIV testing, treatment, viral suppression, and male circumcision following a community-based intervention in Botswana (Ya Tsie/BCPP): a cluster-randomised trial. The lancet. HIV, 7(6)

Nguyen Duc Duy, Gao Kaifu, Wang Rui, Wei Guowei. (2020). Machine intelligence design of 2019-nCoV drugs

Rhee C, Li Z, Wang R, Song Y, Kadri SS, Septimus EJ, Chen HC, Fram D, Jin R, Poland R, Sands K, Klompas M. (2020). Impact of Risk Adjustment Using Clinical vs Administrative Data on Hospital Sepsis Mortality Comparisons. Open forum infectious diseases, 7(6)

Bing A, Hu Y, Prague M, Hill AL, Li JZ, Bosch RJ, De Gruttola V, Wang R. (2020). Comparison of empirical and dynamic models for HIV viral load rebound after treatment interruption. Statistical communications in infectious diseases, 12(Suppl 1)

Hsu HE, Wang R, Broadwell C, Horan K, Jin R, Rhee C, Lee GM. (2020). Association Between Federal Value-Based Incentive Programs and Health Care-Associated Infection Rates in Safety-Net and Non-Safety-Net Hospitals. JAMA network open, 3(7)

Kim JS, Azarbarzin A, Wang R, Djonlagic IE, Punjabi NM, Zee PC, Koo BB, Soliman EZ, Younes M, Redline S. (2020). Association of novel measures of sleep disturbances with blood pressure: the Multi-Ethnic Study of Atherosclerosis. Thorax, 75(1)

Harrison LJ, Chen T, Wang R. (2019). Power calculation for cross-sectional stepped wedge cluster randomized trials with variable cluster sizes. Biometrics

Xu Y, Laeyendecker O, Wang R. (2019). Cross-sectional human immunodeficiency virus incidence estimation accounting for heterogeneity across communities. Biometrics, 75(3)

Rhee C, Wang R, Song Y, Zhang Z, Kadri SS, Septimus EJ, Fram D, Jin R, Poland RE, Hickok J, Sands K, Klompas M. (2019). Risk Adjustment for Sepsis Mortality to Facilitate Hospital Comparisons Using Centers for Disease Control and Prevention's Adult Sepsis Event Criteria and Routine Electronic Clinical Data. Critical care explorations, 1(10)

Kahn R, Hitchings M, Wang R, Bellan SE, Lipsitch M. (2019). Analyzing Vaccine Trials in Epidemics With Mild and Asymptomatic Infection. American journal of epidemiology, 188(2)

Hitchings MDT, Lipsitch M, Wang R, Bellan SE. (2018). Competing Effects of Indirect Protection and Clustering on the Power of Cluster-Randomized Controlled Vaccine Trials. American journal of epidemiology, 187(8)

Wang R, De Gruttola V. (2017). The use of permutation tests for the analysis of parallel and stepped-wedge cluster-randomized trials. Statistics in medicine, 36(18)

Wang R, Dong Y, Weng J, Kontos EZ, Chervin RD, Rosen CL, Marcus CL, Redline S. (2017). Associations among Neighborhood, Race, and Sleep Apnea Severity in Children. A Six-City Analysis. Annals of the American Thoracic Society, 14(1)

Patel SR, Weng J, Rueschman M, Dudley KA, Loredo JS, Mossavar-Rahmani Y, Ramirez M, Ramos AR, Reid K, Seiger AN, Sotres-Alvarez D, Zee PC, Wang R. (2015). Reproducibility of a Standardized Actigraphy Scoring Algorithm for Sleep in a US Hispanic/Latino Population. Sleep, 38(9)

Wang R, Schoenfeld DA, Hoeppner B, Evins AE. (2015). Detecting treatment-covariate interactions using permutation methods. Statistics in medicine, 34(12)

Wang R, Goyal R, Lei Q, Essex M, De Gruttola V. (2014). Sample size considerations in the design of cluster randomized trials of combination HIV prevention. Clinical trials (London, England), 11(3)

Wang R, Weng J, Moyo S, Pain D, Barr CD, Maruapula D, Mongwato D, Makhema J, Novitsky V, Essex M. (2013). Short communication: effect of short-course antenatal zidovudine and single-dose nevirapine on the BED capture enzyme immunoassay levels in HIV type 1 subtype C infection. AIDS research and human retroviruses, 29(6)

Novitsky V, Wang R, Rossenkhan R, Moyo S, Essex M. (2013). Intra-host evolutionary rates in HIV-1C env and gag during primary infection. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, (19)

Wang R, Bosch RJ, Benson CA, Lederman MM. (2012). Drug-resistant virus has reduced ability to induce immune activation. Journal of acquired immune deficiency syndromes (1999), 61(4)

Claggett B, Lagakos SW, Wang R. (2012). Augmented cross-sectional studies with abbreviated follow-up for estimating HIV incidence. Biometrics, 68(1)

Wang R, Ware JH. (2013). Detecting moderator effects using subgroup analyses. Prevention science : the official journal of the Society for Prevention Research, 14(2)

Novitsky V, Wang R, Margolin L, Baca J, Rossenkhan R, Moyo S, van Widenfelt E, Essex M. (2011). Transmission of single and multiple viral variants in primary HIV-1 subtype C infection. PloS one, 6(2)

Wang R, Lagakos SW, Gray RJ. (2010). Testing and interval estimation for two-sample survival comparisons with small sample sizes and unequal censoring. Biostatistics (Oxford, England), 11(4)


Wang R, Lagakos SW. (2010). Augmented cross-sectional prevalence testing for estimating HIV incidence. Biometrics, 66(3)

Novitsky V, Wang R, Kebaabetswe L, Greenwald J, Rossenkhan R, Moyo S, Musonda R, Woldegabriel E, Lagakos S, Essex M. (2009). Better control of early viral replication is associated with slower rate of elicited antiviral antibodies in the detuned enzyme immunoassay during primary HIV-1C infection. Journal of acquired immune deficiency syndromes (1999), 52(2)

Novitsky V, Wang R, Margolin L, Baca J, Kebaabetswe L, Rossenkhan R, Bonney C, Herzig M, Nkwe D, Moyo S, Musonda R, Woldegabriel E, van Widenfelt E, Makhema J, Lagakos S, Essex M. (2009). Timing constraints of in vivo gag mutations during primary HIV-1 subtype C infection. PloS one, 4(11)

Wang R, Lagakos SW. (2009). On the use of adjusted cross-sectional estimators of HIV incidence. Journal of acquired immune deficiency syndromes (1999), 52(5)

Wang R, Lagakos SW. (2009). Inference after variable selection using restricted permutation methods. The Canadian journal of statistics = Revue canadienne de statistique, 37(4)

Wang R, Lagakos SW, Ware JH, Hunter DJ, Drazen JM. (2007). Statistics in medicine--reporting of subgroup analyses in clinical trials. The New England journal of medicine, 357(21)

If you’d like to update your profile, please email modifications to

This site is registered on as a development site.