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Gap junction-mediated antigen transport in immune responses.

Abstract

Communication between cells is a crucial part of the immune response. The importance of cytokines and immunological synapses for this purpose has long been recognized. Connexin-based gap junctions that allow exchange of molecules between adjacent cells also seem to have an important role. Recent work suggests that gap junction-mediated antigen transport might be a mechanism of immune-response regulation. Here, we discuss this idea in more detail and suggest possible ways in which this mechanism might have both positive and negative impacts during an immune response.

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