Paper Information

This retrospective cohort study analyzed adults with incident medically attended all-cause AGE or cause-specified norovirus AGE episodes identified via International Classification of Diseases, Tenth Revision, Clinical Modification between July 1, 2022 and June 30, 2024 in Optum's deidentified Clinformatics® Data Mart Database (Optum® CDM). Generalized estimating equations estimated adjusted risk ratios (aRRs) and confidence intervals (CIs) for acute hospitalization within 3 days of AGE diagnoses.

Underlying conditions, notably CVD and ≥2 underlying conditions, significantly increased the risk of acute hospitalization, which was elevated among adults aged 18-64 years.

Norovirus is a leading cause of acute gastroenteritis (AGE) in the United States and is associated with substantial healthcare utilization, including risk of hospitalization. The extent to which underlying medical conditions contribute to this risk is not well understood.

Of 1 705 514 all-cause AGE and 5805 norovirus AGE cases, 11.3% and 44.6%, respectively, were hospitalized within 3 days of their episode. Hospitalization risk was higher for patients with cardiovascular disease (CVD) (all-cause AGE aRR: 1.67 [95% CI, 1.64-1.69]; norovirus AGE aRR: 1.37 [1.22-1.54]), blood disorders, chronic respiratory disease, and chronic kidney disease. Relative to individuals without underlying conditions, hospitalization risk was higher for those with ≥2 conditions (all-cause AGE aRR: 2.02 [95% CI, 1.98-2.07]; norovirus AGE aRR: 1.79 [1.50-2.14]), exceeding the risk among those with 1 condition. Relative risk of acute hospitalization associated with presence of underlying conditions was higher among adults aged 18-64 years than among those ≥65 years.