Objective: to establish the association between obesity and overweight, menopausal symptoms and impaired quality of life in a group of Colombian women Methods: cross-sectional study that is part of the proyecto de investigación Calidad de Vida en la Menopausia y Etnias Colombianas (CAVIMEC), involving indigenous, black and mestizo Colombian women of the Caribe and Pacific coasts. Menopause Rating Scale (MRS) validated Spanish version was applied anonymously and voluntarily in their community of residence with door to door visits. Women were grouped according to Body Mass Index (BMI). Results: study population: 2167 women. Average age: 48.6 ± 5.9 years. BMI: 25.4 ± 4.2. Normal BMI: 44.2%, underweight: 3.5%, overweight: 40.1%, obese: 12.0%. Premenopausal: 35.0% and postmenopausal women: 41.5%. Average age of menopause: 47.4 ± 3.7 and mean number of years since the last bleeding: 6.0 ± 4.1 years. The average age of menopause increased slightly with increasing BMI (p = 0.027). The prevalence of all menopausal symptoms and the deterioration of dimensions increased with increasing BMI. Overweight had adjusted OR: 1.61 (1.35-1.93) and obesity had adjusted OR 1.40 (1.06-1.84) for severe impairment of quality of life. Conclusions: overweight and obesity are associated with increased menopausal symptoms, greater somatic, psychological and urogenital impairment and more severe impairment of quality of life.