Wen Ye
Associate Research Scientist
University of Michigan Continue Reading Wen Ye
MIDAS Network Member
Paper Information
Title
Serum Biomarkers Correlated with Liver Stiffness Assessed in a Multi-center Study of Pediatric Cholestatic Liver Disease.
Abstract
Endoglin, IL-8, and MMP-7 significantly correlate with increased LSM in children with BA, while CTGF inversely correlates with LSM in A1AT; these biomarkers appear to enhance prediction of LSM beyond clinical tests. Future disease-specific investigations of change in these biomarkers over time and as predictors of clinical outcomes will be important.
from 0.524 to 0.577 (p=0.0033). Biomarkers did not correlate with LSM in ALGS. A significant number of biomarker/lab correlations were found in BA but not A1AT or ALGS.
Detailed investigation of the biological pathways leading to hepatic fibrosis and identification of liver fibrosis biomarkers may facilitate early interventions for pediatric cholestasis.
Journal
Hepatology (Baltimore, Md.)
Citation
Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS, Rosenthal P, McKiernan P, Loomes KM, Jensen MK, Horslen S, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, . (2022). Serum Biomarkers Correlated with Liver Stiffness Assessed in a Multi-center Study of Pediatric Cholestatic Liver Disease. Hepatology (Baltimore, Md.)
MIDAS Authors