
John Brownstein
Chief Innovation Officer
Boston Children’s Hospital Continue Reading John Brownstein
Retrospective evaluation of real-time estimates of global COVID-19 transmission trends and mortality forecasts.
Since 8th March 2020 up to the time of writing, we have been producing near real-time weekly estimates of SARS-CoV-2 transmissibility and forecasts of deaths due to COVID-19 for all countries with evidence of sustained transmission, shared online. We also developed a novel heuristic to combine weekly estimates of transmissibility to produce forecasts over a 4-week horizon. Here we present a retrospective evaluation of the forecasts produced between 8th March to 29th November 2020 for 81 countries. We evaluated the robustness of the forecasts produced in real-time using relative error, coverage probability, and comparisons with null models. During the 39-week period covered by this study, both the short- and medium-term forecasts captured well the epidemic trajectory across different waves of COVID-19 infections with small relative errors over the forecast horizon. The model was well calibrated with 56.3% and 45.6% of the observations lying in the 50% Credible Interval in 1-week and 4-week ahead forecasts respectively. The retrospective evaluation of our models shows that simple transmission models calibrated using routine disease surveillance data can reliably capture the epidemic trajectory in multiple countries. The medium-term forecasts can be used in conjunction with the short-term forecasts of COVID-19 mortality as a useful planning tool as countries continue to relax public health measures.
PloS one
Bhatia S, Parag KV, Wardle J, Nash RK, Imai N, Elsland SLV, Lassmann B, Brownstein JS, Desai A, Herringer M, Sewalk K, Loeb SC, Ramatowski J, Cuomo-Dannenburg G, Jauneikaite E, Unwin HJT, Riley S, Ferguson N, Donnelly CA, Cori A, Nouvellet P. (2023). Retrospective evaluation of real-time estimates of global COVID-19 transmission trends and mortality forecasts. PloS one, 18(10)

Chief Innovation Officer
Boston Children’s Hospital Continue Reading John Brownstein

Department Head
Imperial College London Continue Reading Neil Ferguson

Research Associate
Imperial College London Continue Reading Sangeeta Bhatia

Professor of Infectious Disease Dynamics
Imperial College London Continue Reading Steven Riley