Reza Yaesoubi

Assistant Professor




Dr. Yaesoubi’s research focuses on medical decision making and model-based evaluation of health policies. His work incorporates mathematical and computer simulation models, statistical methods, and optimization techniques to guide resource allocation and decision making in public health and health delivery systems. He has applied these methods in conducting cost-effectiveness analyses of colorectal cancer screening strategies, estimating societal willingness-to-pay for health, and characterizing performance-based payment systems for preventive care systems. His current work mainly focuses on adaptive decision making to control the spread of infectious diseases including tuberculosis, influenza, and meningitis. He is also interested in theoretical and methodological issues in medical decision making including cost-effectiveness analysis, large-scale simulation modeling, Markov decision processes, approximate dynamic programming, game theory, and principal-agent models.

Preferred Pronouns


Personal Academic Website

Research/Topics of Interest

Agent-based models
Antibiotic resistance
Apply models to public health
Between-host modeling
Compartmental models
Decision models
Health systems
Machine learning models
New methods development
Outbreak science
Public health application of models
Surveillance/case detection
Decision science
Antimicrobial resistance
Sequential decision making
Machine Learning

Pathogens/Diseases of Main Interest/Expertise

Pandemic influenza
Sexually transmitted diseases
Tuberculosis (TB)

Countries of Work/Collaboration

United States
South Africa



You S, Chitwood MH, Gunasekera KS, Crudu V, Codreanu A, Ciobanu N, Furin J, Cohen T, Warren JL, Yaesoubi R. (2022). Predicting resistance to fluoroquinolones among patients with rifampicin-resistant tuberculosis using machine learning methods. PLOS digital health, 1(6)

Tu LH, Malhotra A, Sheth KN, Yaesoubi R, Forman HP, Venkatesh AK. (2022). Yield of Head Computed Tomography Examinations for Common Psychiatric Presentations and Implications for Medical Clearance From a 6-Year Analysis of Acute Hospital Visits. JAMA internal medicine

de Villiers AK, Dye C, Yaesoubi R, Cohen T, Marx FM. (2022). Spatially targeted digital chest radiography to reduce tuberculosis in high-burden settings: A study of adaptive decision making. Epidemics, (38)

Yaesoubi R, Cohen T, Hsu K, Gift TL, St Cyr SB, Salomon JA, Grad YH. (2022). Evaluating spatially adaptive guidelines for the treatment of gonorrhea to reduce the incidence of gonococcal infection and increase the effective lifespan of antibiotics. PLoS computational biology, 18(2)

Lee K, You S, Li Y, Chesson H, Gift TL, Berruti AA, Hsu K, Yaesoubi R, Salomon JA, Rönn M. (2022). Estimation of the Lifetime Quality-Adjusted Life Years (QALYs) Lost Due to Syphilis acquired in the United States in 2018. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Tu LH, Malhotra A, Venkatesh AK, Taylor RA, Sheth KN, Forman HP, Yaesoubi R. (2021). Head and Neck CTA Utilization: Analysis of Ordering Frequency and Nonroutine Results Communication, With Focus on the Fifty Most Common Emergency Department Clinical Presentations. AJR. American journal of roentgenology

Yaesoubi R, Havumaki J, Chitwood MH, Menzies NA, Gonsalves G, Salomon JA, Paltiel AD, Cohen T. (2021). Adaptive Policies to Balance Health Benefits and Economic Costs of Physical Distancing Interventions during the COVID-19 Pandemic. Medical decision making : an international journal of the Society for Medical Decision Making

Yaesoubi R, Mahin M, Martin G, Paltiel AD, Sharifi M. (2021). Reducing the Prevalence of Alcohol-Exposed Pregnancies in the United States: A Simulation Modeling Study. Medical decision making : an international journal of the Society for Medical Decision Making

Tu LH, Venkatesh AK, Malhotra A, Taylor RA, Sheth KN, Forman HP, Yaesoubi R. (2021). Scenarios to improve CT head utilization in the emergency department delineated by critical results reporting. Emergency radiology

Marx FM, Cohen T, Menzies NA, Salomon JA, Theron G, Yaesoubi R. (2020). Cost-effectiveness of post-treatment follow-up examinations and secondary prevention of tuberculosis in a high-incidence setting: a model-based analysis. The Lancet. Global health, 8(9)

Hsieh YL, Jahn A, Menzies NA, Yaesoubi R, Salomon JA, Girma B, Gunde L, Eaton JW, Auld A, Odo M, Kiyiika CN, Kalua T, Chiwandira B, Mpunga JU, Mbendra K, Corbett L, Hosseinipour MC, Cohen T, Kunkel A. (2020). An evaluation of 6-month versus continuous isoniazid preventive therapy for M. tuberculosis in adults living with HIV/AIDS in Malawi. Journal of acquired immune deficiency syndromes (1999), 85(5)

Leuba SI, Yaesoubi R, Antillon M, Cohen T, Zimmer C. (2020). Tracking and predicting U.S. influenza activity with a real-time surveillance network. PLoS computational biology, 16(11)

Yaesoubi R, Havumaki J, Chitwood MH, Menzies NA, Gonsalves G, Salomon J, Paltiel AD, Cohen T. (2020). Adaptive policies for use of physical distancing interventions during the COVID-19 pandemic. medRxiv : the preprint server for health sciences

Yaesoubi R, Cohen T, Hsu K, Gift TL, Chesson H, Salomon JA, Grad YH. (2020). Adaptive guidelines for the treatment of gonorrhea to increase the effective life span of antibiotics among men who have sex with men in the United States: A mathematical modeling study. PLoS medicine, 17(4)

Yap A, Cheung M, Muzira A, Healy J, Kakembo N, Kisa P, Cunningham D, Youngson G, Sekabira J, Yaesoubi R, Ozgediz D. (2019). Best Buy in Public Health or Luxury Expense?: The Cost-effectiveness of a Pediatric Operating Room in Uganda From the Societal Perspective. Annals of surgery

Kaufhold S, Yaesoubi R, Pitzer VE. (2019). Predicting the Impact of Typhoid Conjugate Vaccines on Antimicrobial Resistance. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 68(Supplement_2)

Arifin SMN, Zimmer C, Trotter C, Colombini A, Sidikou F, LaForce FM, Cohen T, Yaesoubi R. (2019). Cost-Effectiveness of Alternative Uses of Polyvalent Meningococcal Vaccines in Niger: An Agent-Based Transmission Modeling Study. Medical decision making : an international journal of the Society for Medical Decision Making, 39(5)

Yap A, Muzira A, Cheung M, Healy J, Kakembo N, Kisa P, Cunningham D, Youngson G, Sekabira J, Yaesoubi R, Ozgediz D. (2018). A Cost-Effectiveness Analysis of a Pediatric Operating Room in Uganda. Surgery, 164(5)

Marx FM, Yaesoubi R, Menzies NA, Salomon JA, Bilinski A, Beyers N, Cohen T. (2018). Tuberculosis control interventions targeted to previously treated people in a high-incidence setting: a modelling study. The Lancet. Global health, 6(4)

Menzies NA, Cohen T, Hill AN, Yaesoubi R, Galer K, Wolf E, Marks SM, Salomon JA. (2018). Prospects for Tuberculosis Elimination in the United States: Results of a Transmission Dynamic Model. American journal of epidemiology, 187(9)

Zimmer C, Leuba SI, Cohen T, Yaesoubi R. (2019). Accurate quantification of uncertainty in epidemic parameter estimates and predictions using stochastic compartmental models. Statistical methods in medical research, 28(12)

Menzies NA, Wolf E, Connors D, Bellerose M, Sbarra AN, Cohen T, Hill AN, Yaesoubi R, Galer K, White PJ, Abubakar I, Salomon JA. (2018). Progression from latent infection to active disease in dynamic tuberculosis transmission models: a systematic review of the validity of modelling assumptions. The Lancet. Infectious diseases, 18(8)

Zimmer C, Leuba SI, Yaesoubi R, Cohen T. (2018). Use of daily Internet search query data improves real-time projections of influenza epidemics. Journal of the Royal Society, Interface, 15(147)

Yaesoubi R, Trotter C, Colijn C, Yaesoubi M, Colombini A, Resch S, Kristiansen PA, LaForce FM, Cohen T. (2018). The cost-effectiveness of alternative vaccination strategies for polyvalent meningococcal vaccines in Burkina Faso: A transmission dynamic modeling study. PLoS medicine, 15(1)

Zimmer C, Yaesoubi R, Cohen T. (2017). A Likelihood Approach for Real-Time Calibration of Stochastic Compartmental Epidemic Models. PLoS computational biology, 13(1)

Yaesoubi R, Cohen T. (2016). Identifying cost-effective dynamic policies to control epidemics. Statistics in medicine, 35(28)

Yaesoubi R, Cohen T. (2013). Identifying dynamic tuberculosis case-finding policies for HIV/TB coepidemics. Proceedings of the National Academy of Sciences of the United States of America, 110(23)

Yaesoubi R, Roberts SD. (2011). Payment contracts in a preventive health care system: a perspective from operations management. Journal of health economics, 30(6)

Yaesoubi R, Cohen T. (2011). Dynamic health policies for controlling the spread of emerging infections: influenza as an example. PLoS One, 6(9)

Yaesoubi R, Cohen T. (2011). Generalized Markov Models of Infectious Disease Spread: A Novel Framework for Developing Dynamic Health Policies. European journal of operational research, 215(3)

Joseph P Bigus, Murray Campbell, Boaz Carmeli, Melissa Cefkin, Henry Chang, C-H Chen-Ritzo, William F Cody, Shahram Ebadollahi, A Evfimievski, Ariel Farkash, Susanne Glissmann, David Gotz, TWA Grandison, Daniel Gruhl, Peter J Haas, Mark JH Hsiao, P-YS Hsueh, Jianying Hu, Joseph M Jasinski, James H Kaufman, Cheryl A Kieliszewski, Martin S Kohn, Sarah E Knoop, Paul P Maglio, Ronald L Mak, Haim Nelken, Chalapathy Neti, Hani Neuvirth, Yue Pan, Yardena Peres, Sreeram Ramakrishnan, Reza Yaesoubi. (2011). Information technology for healthcare transformation. IBM Journal of Research and Development, 55(5)

Yaesoubi R, Roberts SD. (2010). A game-theoretic framework for estimating a health purchaser's willingness-to-pay for health and for expansion. Health care management science, 13(4)

Reza Yaesoubi, Stephen D Roberts, Robert W Klein. (2010). A modification of Cheng's method: An alternative Factor Screening method for stochastic simulation models. Proceedings of the 2010 Winter Simulation Conference

R. Yaesoubi and S. D. Roberts. (2008). How much is a health insurer willing to pay for Colorectal Cancer screening tests?. 2008 Winter Simulation Conference

Reza Yaesoubi, Stephen D Roberts. (2007). Important factors in screening for colorectal cancer. 2007 Winter Simulation Conference


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